盐酸舒托必利注射液临床疗效研究  

The Clinical Study of the Therapeutic Efficacy of Sultopride Hydrochloride Injection

作　　者：徐鹤定[1] 蔡军[1] 朱敏捷[1] 王祖承[2] 

机构地区：[1]上海市精神卫生中心临床三科,200030 [2]上海第二医科大学精神医学教研室,200030

出　　处：《医药导报》2001年第8期489-490,共2页Herald of Medicine

摘　　要：目的 :验证盐酸舒托必利的疗效及安全性。方法 :对 15 0例精神分裂症、情感性精神障碍、智力发育不全、乙醇中毒所致精神障碍患者进行盐酸舒托必利治疗的随机双盲对照研究 ,采用BPRS、BRMS量表评定临床疗效 ,采用TESS量表评定不良反应。结果 :BPRS激惹因子评分两组比较差异有极显著性 (P <0 .0 1) ;BRMS、BRMS评分两组比较差异分别有显著性和极显著性 (P <0 .0 5及P <0 .0 1) ;TESS总评分显示两组比较差异无显著性。结论 :盐酸舒托必利有较好的控制兴奋躁动及镇静作用 ,临床疗效确切 ,不良反应轻微。Objective:To determine the efficacy and safety of sultopride hydrochloride injection in treating patients with psychiatric disorders. Methods:A Random, double-blinded control study was carried out. 150 patients who met the CCMD-Ⅱ criteria of schizophrenia, mood disorders, mental retardation and alcoholic disorders were recruited for the study. 100 patients were treated wit sultopride hydrochloride injection and the others with sulpiride hydrochloride injection(100-300 mg·d -1 ) for one week. The efficacy was assessed by brief psychiatric rating scale (BPRS) and bech-rafaelsen mania scale (BRMS). The safety was assessed by treatment emergent symptom scale(TESS). Results:The BPRS agitation score, The BRMS score and the reduction of BRMS score were significantly different between the two groups(P<0.01, 0.05 and 0.01, Respectively). No difference in the total score of TESS was revealed between the two groups. Conclusion:Sultopride hydrochloride injection is an effective and safe agent for the treatment of patients with excitement symptoms.

关 键 词：精神分裂症 盐酸舒手利注射液 治疗 疗效 安全性 

分 类 号：R971.41[医药卫生—药品] R749.3[医药卫生—药学]