超临界连续GAS过程制备对苯二酚超细颗粒  

Research on Continuous Gas Anti-solvent Crystallization of Hydroquinone Using a Supercritical Fluid

作　　者：Serge R Bitemo 洪镭[1] 刘昆[1] 高勇[2] 

机构地区：[1]华东理工大学联合化学反应工程研究所,上海200237 [2]华东理工大学化学与制药学院,上海200237

出　　处：《华东理工大学学报（自然科学版）》2001年第4期338-340,共3页Journal of East China University of Science and Technology

基　　金：上海市自然科学基金资助项目 (978F14 0 40 ) ;曙光计划资助项目 (98SG12 )

摘　　要：建立了一套连续的气体抗溶剂实验装置。以对苯二酚 -丙酮 -二氧化碳物系为研究对象 ,利用超临界流体抗溶剂过程制备了对苯二酚超细颗粒并将其结果与文献进行了比较 ,从而验证了装置的可靠性。同时 ,对不同的溶液浓度和溶液流量对结晶颗粒形貌与尺寸的影响进行了研究。结果表明 ,溶液流量增大颗粒粒径减小 ,而溶液浓度增大颗粒粒径增加 ;溶液流量较大时 ( 1 2 .0 0 L/min) ,产品颗粒为菱形晶体 ,溶液流量较小时 ( 2 .0 0 L/min) ,产品颗粒为棒状晶体 ;A continuous gas anti solvent apparatus has been constructed in this research. With hydroquinone acetone carbon dioxide system as a test background, GAS process using supercritical CO 2 is utilized to prepare super fine particles. Comparisons between our results and reference are made to check reliability of the apparatus and influences of solution concentration and flow rate on size and morphology of produced particles are investigated. The results obviously showed that a higher primary solution concentration lead to a decrease in size of the sample particles and a higher primary solution concentration to an increase. The prismatic crystals are formed at high flow rate (12.0mL/min) while the needles created at relatively low flow rate (2.0mL/min).

关 键 词：超临界流体 连续抗溶剂过程 对苯二酚 超细颗粒 制备 溶液浓度 溶液流量 

分 类 号：TQ243.12[化学工程—有机化工]