高压氧对老龄小鼠记忆行为和脑内脂褐素含量的影响  

The effect of hyperbaric oxygen on memory behavior and lipofuscin content of brain in aged-mice

作　　者：徐晓虹[1] 郭丹 

机构地区：[1]浙江师范大学生命与环境科学学院,浙江金华321004 [2]南京海军高等医学专科学校,江苏南京210099

出　　处：《浙江师大学报（自然科学版）》2001年第1期67-69,共3页Journal of Zhejiang Normal University(Natoral Sciences)

摘　　要：用开场行为模型和一次性被动回避反应模型分别对经高压氧处理的老龄小鼠进行自发活动和记忆保持力检测 ,并用荧光分光光度计测定脑内脂褐素含量 ,探讨了高压氧 ( HBO)对衰老性学习记忆障碍的作用及其与脑内脂褐素含量的关系 .结果表明 :( 1 )高压氧可明显增强老龄小鼠在新异环境中的自发活动 ,显著提高其记忆保持力 ;( 2 )高压氧使老龄小鼠脑内脂褐素含量明显下降 .提示高压氧可改善衰老性记忆障碍 。The spontaneous behavior and learning memory retention of aged-mice were assessed by using open field and one-trial passive avoidance task after atmospheric (0.10 MPa) oxygen or hyperbaric (0.25 MPa) oxygen treatment (HBOT). At the same time, the brain lipofuscin content of aged-mice were measured by spectrofluorophotometer. The results were as follows: (1)The spontaneous behavior and explorative response in the open field significantly increased and the memory retention were remarkably elevated by atmospheric oxygen or HBOT. (2) The content of brain lipofuscin were decreased after atmospheric oxygen or HBOT, and there was a better inhibition action of HBOT on high level of lipofuscin in the brain. The findings suggested that the senile memory impediment could be treated by HBOT through decreasing the content of brain lipofuscin in aged-mice.

关 键 词：高压氧 开场行为 一次性被动回避反应 脂褐素 自发活动 记忆保持力 衰老性记忆障碍 

分 类 号：Q427[生物学—神经生物学]