僵蚕抗实验性静脉血栓及作用机理的研究  

Effects of Batryticated Silkworm on Experimental Venous Thrombosis and its Mechanism

作　　者：彭延古[1] 李露丹[1] 邓奕辉[1] 

机构地区：[1]湖南中医学院,长沙410007

出　　处：《血栓与止血学》2001年第3期104-105,共2页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的:为研究僵蚕抗实验性血栓的作用。方法:用Beyers制作静脉血栓动物模型进行观察。结果:表明静脉注射僵蚕液后,模型动物的血栓重量明显减轻(P<0.01),纤溶酶原含量、纤维蛋白原含量、优球蛋白溶解时间明确减少(P<0.05),同时激活部分凝血活酶时间(KPTT)、凝血酶原时间(PT)、凝血酶时间(TT)均有明显延长(P<0.01)。结论:说明僵蚕具有促纤溶活性,对凝血酶一纤维蛋白原反应的直接抑制作用为防止血栓形成的主要因素。Objective: To study the effects of batryticated silkworm on experimental antithrombosis. Methods: Observe the venous thrombsis mouse model its made by beyers. Results: Showed that when compared with the control, the weight of the thrombus were reduced obviously(P<0. 01), after the batryticated silkworm solution was intravenously infused. The contents of plasminogen, fibrinogen and euglobulin lysis time were remarkably reduced. Meanwhile, kaolin partial thromboplastin time(KPTT), prothrombin time(PT), thrombin time(TT) were significantly prolonged(P<0.01). Conclusion: These facts indicated that batryticated silkworm can promote fibrinolytic activity and inhibit the coagulation process.

关 键 词：僵蚕 血栓形成 纤溶活性 抗凝剂 实验性静脉血栓 

分 类 号：R543[医药卫生—心血管疾病]