补肾活血、泻下及开窍活血方药对老龄大鼠脑缺血再灌注肝脏损伤的保护作用  

The Protective Action of Drugs with the Functions of Reinforcing Kidney and Promoting Blood Flow, Drugs with Purgative Function and Drugs with the Functions of Inducing Resuscitation and Promoting Blood Flow on Aged Rats with Liver Injury Caused

作　　者：李建生[1] 李建国[1] 高爱社[1] 赵君玫[1] 郭盛典[1] 张卫红[1] 赵晶[1] 

机构地区：[1]河南中医学院老年医学研究室,河南郑州450008

出　　处：《河南中医》2001年第4期14-17,共4页Henan Traditional Chinese Medicine

基　　金：河南省杰出青年基金资助 (1999- 0 5 ) ;河南省创新人才基金项目 (2 0 0 0 - 10 )

摘　　要：将老龄大鼠分为老龄对照组、老龄模型组、尼莫地平组、益元活血丹大小剂量组、大黄组和血栓心脉宁组 ,观察大鼠全脑缺血 30min、再灌注 6 0min后肝脏形态和组织中TXB2 、6 -Keto -PGF1a、TNF含量、ATP酶活性及组织和血清中ALT活性的变化。结果表明 :老龄模型组肝脏出现明显的病理和功能损伤。The aged rats were divided into control group, model group, Nimodipine group, Yi Yuan Huo Xue Dan (YYHXD) group with large dose, YYHXD group with small dose, Rhubarb group and Xue Shuan Xin Mai Ning (XSXMN) group to observe factors hereinafter. They include the liver histolomorph, the content of TXB2, 6-Keto-PGF1a and TNF in tissues, ATP activity, and changes of ALT in tissues and serum. It reveals obvious pathological changes and functional injury in liver in the model group, while tissue functional injury of the liver in groups treated with medicines alleviates at different levels.

关 键 词：补肾活血药 泻下药 开窍活血药 大鼠 脑缺血 肝脏损伤 保护作用 

分 类 号：R285[医药卫生—中药学] R277.733.1[医药卫生—中医学]