乙型肝炎患者白细胞介素2与病毒e系统及HBVDNA关系的观察  

Relationship between Interleukin-2 and HBV-markers in Hepatitis B

作　　者：张蔚卿[1] 刘厚钰[1] 郑湘蓉 顾桂玲[1] 童家琪[1] 

机构地区：[1]上海医科大学附属中山医院

出　　处：《临床肝胆病杂志》1991年第1期10-12,共3页Journal of Clinical Hepatology

摘　　要：根据不同的乙肝病毒标志,将患者分成四组:HBeAg(+)组,抗HBe(+)组;HBVDNA(+)组(包括DNAP同时阳性);及“四阴组” (e系统、HBVDNA、DNAP及抗HBc-IgM均阴性,其它乙肝病毒标志可阳性)。比较他们的血清IL-2值,结果如下:1.四组患者的IL-2水平都极显著低于健康对照组(p<0.01)。2.与“四阴组”比较,HBeAg(+)组偏低明显(p<0.01),HBVDNA(+)组偏低比较明显(p<0.05),抗HBe(+)组不显示差异(p>0.05)。3.HBeAg(+)组、抗HBe(+)组及HBVDNA(+)组之间IL-2无明显差异(p>0.05)。29 patients with hepatitis B virus infection were divided into four groups according to HBV markers—e system and HBVDNA in their serum.i.e. HBeAg positive, anti-HBe positive, HBV-DNA positive (DNAP positive as well),and negative for all above markers. Interluekin-2 (IL-2) was determined with CTLL ~3H-Tdr incorporation assay. Its activity was significantly decreased in all four groups comparing with that of healthy controls (P<0.01). Meanwhile, IL-2 activity was relatively lower in HBeAg and HBV-DNA positive patients than that of patients negative for all 4 markers (P<0.01 and P<0.05, respectively). No significant diference of IL-2 level were noted between HBeAg positive, HBV-DNA positive and anti-HBe positive patients groups.

关 键 词：乙型肝炎 TL-2 E系统 HBV DNV 

分 类 号：R512.620.3[医药卫生—内科学]