支气管哮喘发病中细胞因子的作用  

The Role of Cytokine in the Pathogenesis of Bronchial Asthma

作　　者：柳喆[1] 杨淑华[1] 李秋根[2] 漆基建[2] 苏钢[2] 

机构地区：[1]江西省医学科学研究所生化研究室 [2]江西省肺科医院呼吸内科

出　　处：《江西医学院学报》1999年第1期7-9,共3页Acta Academiae Medicinae Jiangxi

基　　金：国家卫生部课题

摘　　要：目的：了解Ｔ－Ｂ淋巴细胞在哮喘发病中的作用，嗜酸粒细胞（ＥＯＳ），可溶性白细胞介素－２受体（ＳＩＬ－２Ｒ），ＩｇＥ和Ｔ淋巴细胞亚群（ＣＤ３、ＣＤ４、ＣＤ８），人类组织相关抗原（ＨＬＡ－ＤＲ）百分率表达与气道高反应（ＡＨＲ）的关系。方法：３０例支气管哮喘患者口服强的松２０ｍｇ／ｄ，疗程一周，治疗前后检测肺功能最高峰值流速（ＰＥＦ），第一秒用力呼气容量（ＦＥＶ１），并检测外周血ＥＯＳ、ＳＩＬ－２Ｒ、ＩｇＥ、ＣＤ３、ＣＤ４、ＣＤ８和ＨＬＡ－ＤＲ百分率。结果：ＥＯＳ、ＳＩＬ－２Ｒ、ＩｇＥ水平及ＣＤ４、ＨＬＡ－ＤＲ百分率明显下降（Ｐ＜０．０１），而反映通气功能的指标ＰＥＦ，ＦＥＶ１明显好转（Ｐ＜０．０１）。结论：ＥＯＳ、ＳＩＬ－２Ｒ、ＩｇＥ和ＣＤ４、ＨＬＡ－ＤＲ百分率表达增强在哮喘发病中起着重要作用。Objective: To study the role of T and B lymphocytes activation in the pathogenesis of asthma and the relationship of Eos,SIL 2R,IgE and percentages of CD 3,CD 4,CD 8 and HIA DR to AHR .Methods: Pulmonary function tests were performed and percentages of CD 3,CD 4,CD 8 and HLA DR and the levels of Eos,SIL 2R and IgE were determined in 30 asthmatic patients before and after a week of treatment with prednisone.Results: It was found that the levels of Eos,SIL 2R,IgE and percentages of CD 4 and HLA DR were significantly lower ( P <0 01),PEF and FEV 1 increased significantly ( P <0 01).Conclusions: These findings suggest that increased levels of Eos,SIL 2R,IgE and increased expression of the percentages of CD 4 and HLA DR play important roles in the pathogenesis of asthma.

关 键 词：哮喘 免疫活性 T淋巴细胞 哮酸细胞 

分 类 号：R562.25[医药卫生—呼吸系统]