中药大黄的综合研究 XXXI.大黄蒽醌衍生物系统分离的改进方法  

STUDIES ON CHINESE RHUBARB XXXI.Improved Method for Systematic Isolation of Anthraquinone Derivatives from Rhubarb

作　　者：陈琼华[1] 戴汉松[2] 苏学良[3] 

机构地区：[1]中国药科大学生化教研室,南京210010 [2]中国科学院成都有机化学研究所,成都610041 [3]天津医科大学内分泌研究所,天津300070

出　　处：《天然产物研究与开发》2001年第3期58-60,共3页Natural Product Research and Development

摘　　要：西宁大黄小碎片加到 2 0 %硫酸溶液和氯仿的混合液中 ,在水浴中回流以水解、提取。氯仿提取液相继以 5 %碳酸氢钾溶液 ,5 %氢氧化钾溶液振荡提取。提取液分别以盐酸酸化 ,即分离得大黄酸、大黄素、芦荟大黄素及大黄酚和大黄素甲醚混合物等黄色沉淀物。后者再以硅胶柱层析分离 ,可得大黄酚和大黄素甲醚单体。上述五种蒽醌衍生物再经结晶即得纯品。Ground rhizomes of Rhubarb (Rheum Patmatum)were refluxed with 20% H 2SO 4 solution chloroform mixture on water bath.The chloroform extracts were shaken successively with aqueous 5% KHCO 3,5% Na 2CO 3,0 25% KOH and 5% KOH solutions.The aqueous extracts were then acidified with HCl to yield yellow precipitates of rhein,emodin,aloe emodin and crysophanol physcion mixture,respectively,the latter were separated by silica gel column chromatography.All the five substances were further purified by crystallization.

关 键 词：大黄 蒽醌衍生物 系统分离 中药 

分 类 号：R284.2[医药卫生—中药学] R282.71[医药卫生—中医学]