阿卡波糖对糖尿病大鼠主动脉胶原蛋白糖基化的影响  

Effect of acarbose on the aortic collagen nonenzymatic glycosylation in diabetic rats

作　　者：金晖[1] 邓钢[1] 刘乃丰[2] 薛元明[1] 罗尧生[1] 

机构地区：[1]云南省第一人民医院内分泌科,云南昆明650032 [2]南京铁道医学院心血管病研究室,江苏南京210009

出　　处：《中国病理生理杂志》2001年第10期951-953,共3页Chinese Journal of Pathophysiology

摘　　要：目的 :观察新一代α-葡萄糖苷酶抑制剂阿卡波糖 (acarbose)对实验性糖尿病 (DM)大鼠主动脉胶原非酶糖基化的影响。方法 :用链脲佐菌素 ( 5 0mg·kg-1,ip)造成大鼠糖尿病模型 ,分别观察糖尿病组 ,糖尿病 +阿卡波糖组及正常对照组 1、3、6个月病程中各组主动脉胶原及胶原非酶糖基化终产物 (AGEs)量变化 (荧光光谱测定法 )。结果 :糖尿病大鼠主动脉胶原及胶原AGEs含量明显高于正常对照组 ,且随病程延长 ,此种增加更明显 (P <0 0 1) ,而阿卡波糖治疗组胶原及胶原AGEs含量降低 ,与未治疗组相比存在差异 (P <0 0 1)。结论 :阿卡波糖对糖尿病大鼠主动脉胶原蛋白糖基化的形成有抑制作用。AIM: To observe the effect of α-glucosindase inhibitor, acarbose on the aortic collagen nonenzymatic glycosylation in streptozotocin-induced diabetic rats . METHODS: The treated group (DM+A) was given acarbose (1 mg·kg -1 ). The aortic collagen and its AGEs concentration were measured at the scheduled periods (1, 3 and 6 months ). RESULTS: During the observed period , the aortic collagen and its AGEs concentration were higher than that of control group in a time-dependent manner (P<0.01 ), but decreased in acarbose-treated rats as compared with untreated group (P<0.01 ). CONCLUTION:Acarbose can prevent the aortic vascular collagen nonenzymatic glycosylation in diabetic rats.

关 键 词：糖基化 胶原 阿卡波糖 链脲菌素 糖尿病 大鼠 主动脉 

分 类 号：R587.2[医药卫生—内分泌] R543.1[医药卫生—内科学]