瑞香狼毒中新的双黄酮和活性化合物(英文)  

NEW BIFLAVANONES AND BIOACTIVE COMPOUNDS FROM STELLERA CHAMAEJASME L.

作　　者：徐志红[1] 秦国伟[1] 李晓玉[1] 徐任生[1] 

机构地区：[1]中国科学院上海生命科学研究院上海药物研究所,上海200031

出　　处：《药学学报》2001年第9期668-671,共4页Acta Pharmaceutica Sinica

摘　　要：目的　研究中药狼毒药材来源之一瑞香狼毒 (StellerachamaejasmeL)根的化学成分。方法　用各种柱色谱进行分离纯化 ,用各种波谱分析方法鉴定其结构。结果　从瑞香狼毒的根中分离并鉴定出 3种双黄酮和 8种木脂素 :瑞香狼毒素A (1)和B (2 ) ,4 ,4″ ,5 ,5″ ,7,7″ hexahydroxy 3,3″ biflavanone (3) ,(+) kusunokinin (4 ) ,lirioresinol B (5 ) ,magnoleninC (6) ,(- ) pinoresinolmonomethylether (7) ,(- ) pinoresinol(8) ,(+) matairesinol (9) ,isohinokinin (10 )和 (- ) eudesmin (11)。结论　化合物 1和 2为新化合物 ,1是已知双黄酮chamaejasmeninC的对映体 ,4 ,6,8,9,10和 11是从本植物中首次分得 ,7是首次从天然界分得 ,体外生物测试表明 3和 8有抗菌活性 ,1,2 ,9和 11有免疫调节活性。AIM To study the chemical constituents of the root of Stellera chamaejasme L. METHODS Various column chromatographies on silica gel and RP-18 were employed for isolation and purification. Structures of compounds were elucidated by spectral analysis. RESULTS Eight lignans and three biflavonoids possessing a C-3/C-3″ linkage were isolated. They are ruixianglangdusu A (1) and B (2), 4′,4,5,5″,7,7″-hexahydroxy-3,3″-biflavone (3), (+)-kusunokinin (4), lirioresinol-B (5), magnolenin C (6), (-)-pinoresinol monomethyl ether (7), (-)-pinoresinol (8), (+)-matairesinol (9), isohinokinin (10) and (-)-eudesmin (11). CONCLUSION Compounds 1 and 2 are new biflavanones, 1 is enantiomeric to known chamaejasmenin C, 4, 6, 8, 9, 10 and 11 were isolated from this plant for the first time, and 7 was isolated from natural resources for the first time. In vitro bioassays showed that 3 and 8 exhibited antibacterial activity, and 1, 2, 9 and 11 exhibited immunomodulatory activity.

关 键 词：瑞香狼毒 双黄酮 体外生物测定 中药 

分 类 号：R284.1[医药卫生—中药学]