应激在急性出血坏死性胰腺炎所致肺损伤中的作用  

Role of stress in the lung injury caused by acute hemorrhagic necrotizing pancreatitis in rats

作　　者：徐睿[1] 艾中立[1] 刘志苏[1] 孙权[1] 严燕国[1] 何国英[1] 

机构地区：[1]武汉大学中南医院一外科,湖北武汉430071

出　　处：《中国病理生理杂志》2001年第10期1002-1004,T002,共4页Chinese Journal of Pathophysiology

摘　　要：目的 :通过复制大鼠急性出血坏死性胰腺炎 (AHNP)模型 ,探讨在AHNP的发病过程中 ,应激与AH NP及其所致肺损伤的关系。方法 :用 5 %牛磺胆酸钠溶液逆行胰胆管注射制作大鼠AHNP模型。将实验动物随机分为A -C 3组 ,A组为假手术组 ,B组为AHNP组 ,C组在制成AHNP模型后给予甲吡酮 (metyrapone)以控制应激反应的程度 ,观察大鼠血清中皮质醇 ,C反应蛋白 (CRP)及血清淀粉酶的含量 ,以及肺及胰腺的病理组织学。结果 :C组动物血清中皮质醇、CRP及淀粉酶的含量明显低于对照组 ,肺及胰腺的损害程度 ,明显低于对照组 (P <0 0 5 )。结论 :应激在急性出血坏死性胰腺炎并发肺损伤的过程中起了重要作用。运用特异性抗应激药物可以明显减轻其所致的肺损伤。AIM: To study the relation ship between stress and lung injury caused by acute hemorrhagic necrotizing pancreatitis(AHNP) through AHNP model.METHODS: The AHNP model was made by using 5% sodium taurocholate retrograded injection into biliopancreatic duct in SD rats. Those rats were divided into three groups randomly, from A to C, the A group undertook sham operations, the B group was made into AHNP model, and the C group was given Metyrapone. The level of corticosteroid, CRP and amylase in serum had been observed. The lung and pancreas histological examinations were also performed.RESULTS: In C group, the level of corticosteroid, CRP and amylase were much lower than those in B group. The grade of lung and pancreas injury were also lower than those in B group(P<0.05).CONCLUSION: Stress lays an important role in the lung injury caused by AHNP. Using anti-stress drugs can inhibit this course and meliorate the lung injury.

关 键 词：应激 肺损伤 急性出血坏死性胰腺炎 AHNP 大鼠 

分 类 号：R657.51[医药卫生—外科学] R563[医药卫生—临床医学]