人参皂苷Rb_1和Rd对不同类型记忆障碍模型小鼠学习记忆功能的影响  

Effects of ginsenoside Rb_1 and Rd on learning and memory function of mice

作　　者：陈声武[1] 王丽娟[1] 王岩[1] 王本祥[1] 

机构地区：[1]长春中医学院新药研究中心,吉林长春130021

出　　处：《中国药理学与毒理学杂志》2001年第5期330-332,共3页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金资助项目 (395 70 86 1)~~

摘　　要：分别以东莨菪碱 ,环己米特和乙醇致小鼠获得性 ,巩固性和再现性记忆障碍 ,用跳台实验观察人参皂苷Rb1和Rd对学习记忆功能的影响 .结果表明 ,人参皂苷Rb1(10 0 ,5 0mg·kg- 1,ig)和人参皂苷Rd(2 0 ,10mg·kg- 1,ip)每天上午 9:0 0给药 1次 ,连续给药 7d ,对东莨菪碱和环己米特所致的小鼠获得性及巩固性记忆障碍均具有明显的改善作用 ,而对乙醇所致的小鼠记忆再现障碍则无明显影响 .结果表明 ,人参皂苷Rb1(ig)和Rd(ip)对小鼠学习记忆功能有增强作用 .To study the effects of ginsenoside Rb 1 and Rd on learning and memory function of mice with dysmnesia induced by various drugs, the dysmnesia models of memory-acquisition, memory-retention and memory-retrieval were made with scopolamine (1.5 mg·kg -1, ip ), cycloheximide (120 mg·kg -1, ip ) and 30% ethanol (10 mL·kg -1, ig ), respectively. The learning and memory function was determined by step down test. The results showed that ginsenoside Rb 1(100 and 50 mg·kg -1·d -1, ig for 7 d) and Rd (20 and 10 mg·kg -1·d -1, ip for 7 d) obviously alleviated dysmnesia induced by scopolamine and cycloheximide, but both of them have no effects on dysmnesia induced by ethanol. It is suggested that ginsenoside Rd and Rb 1 have preventive effect for dysmnesia.

关 键 词：人参皂苷 人参皂式Rb 人参皂苷RD 记忆障碍 学习记忆功能 

分 类 号：R285[医药卫生—中药学]