老年轻度认知功能损害的脑磁共振显像三维测量研究  

Measurement of brain structural changes in the elderly with mild cognitive impairment using 3-dimentional magnetic resonance images

作　　者：肖世富[1] 昂秋青[1] 姚培芬[1] 刘福根[1] 沈天真[2] 何慧瑾[2] 黄红芳[3] 张选红[1] 江开达[4] 张明园[1] 

机构地区：[1]上海市精神卫生中心老年精神科,200030 [2]上海医科大学附属华山医院磁共振室 [3]上海市精神卫生中心心理测验室,200030 [4]上海市精神卫生中心普通精神科,200030

出　　处：《中华精神科杂志》2001年第3期142-145,共4页Chinese Journal of Psychiatry

基　　金：卫生部科学研究基金资助项目 ( 98 1 32 0 );上海市卫生系统百人计划资助项目 ( 98BR0 33)

摘　　要：目的　研究老年轻度认知功能损害者的脑形态结构变化特点。方法　于 1999年 1月至 2 0 0 0年 6月用脑磁共振显像 (MRI)三维测量法组织分割和体积测量分析技术 ,检查有轻度认知功能损害的老年人 2 1例 (MCI组 )和认知功能正常的老年人 2 9名 (NC组 )。结果　 (1)MRI测量 :与NC组相比 ,MCI组的颅内总体积少 5 2 % ,灰质体积少 8 8% ,灰质百分比少 3 9% ,总脑脊液多 12 3% ,两组差异有显著或非常显著性 (P <0 0 5或P <0 0 1)。 (2 )多元逐步判别分析 :脑灰质和侧脑室体积具有非常显著性判别意义 (P <0 0 1) ,两组判别总正确率为 74 5 %。Objective To Assess the brain structural changes in the elderly with mild cognitive impairment using 3 dimentional magnetic resonance images Methods The elderly subjects with mild cognitive impairment (MCI) and normal controls (NC) were measured with a computerized volumetry and tissue segmentation program to quantify volumes of hippocampal formation (HF), gray matter (GM), white matter (WM), ventricular and Cerebrospinal fluid (CSF) Results Twenty one MCI and 29 NC were recruited Compared with control subjects, the elderly with MCI showed significantly decreased total intracranial volume ( P <0 05), GM volume ( P <0 01), and GM fraction ( P <0 01), and significantly increased CSF fraction ( P <0 05) The intracranial and GM volume decreased by 5 2% and 8 8% respectively, GM fraction decreased by 3 9%, and CSF fraction increased by 12 3% A linear discriminant function was obtained with stepwise discriminant analysis and variables of GM and ventricular volume entered the function ( P <0 00) with a discriminative accuracy of 74 5% Conclusion Three dimensional magnetic resonance image technique may be helpful in understanding the brain structural changes of the elderly with mild cognitive impairment

关 键 词：认知障碍 磁共振成像 老年人 MRI MCI 三维测量 

分 类 号：R445.2[医药卫生—影像医学与核医学]