长期血液透析患者丙型肝炎病毒感染的研究  

Investigation of hepatitis C virus infection in chronic hemodialytic patients

作　　者：程恳[1] 王璐[1] 井新辉[1] 

机构地区：[1]中日友好医院,100086

出　　处：《山西医药杂志》2001年第5期390-392,共3页Shanxi Medical Journal

摘　　要：目的　调查长期血液透析患者丙型肝炎感染状况。方法　用酶联免疫吸附试验 ( EL ISA)法和RT- PCR法检测 13 7例长期血液透析患者血清中的抗丙型肝炎病毒 ( HCV)和丙型肝炎病毒核糖核酸( HCVRNA) ,并且同时检测丙氨酸转氨酶 ( AL T)和天冬氨酸转氨酶 ( AST) ,计算其变动率。结果　 13 7例长期血液透析患者中仅抗 HCV阳性 8例 ,仅 HCVRNA阳性 15例 ,抗 HCV与 HCVRNA同时阳性者 2 4例 ,感染率3 4 .3 %。且透析时间 <2 a的 HCV感染率为 15 % ,透析时间 >2 a以上的其感染率增至 3 7.6%。结论　血透患者中 HCV的感染应引起重视 ,透析的年限越长 ,被 HCV感染的机率就越大。酶学指征的变动率不能作为长期透析患者Objective To investigate the hepatitis C infection in chronic hemodialytic (HD) patients and the change of aminotransferase.Methods One hundred and thirty seven HD patients were evaluated by using ELISA to detect serum anti HCV antibodies,RT PCR to detect serum HCVRNA,and at the same time detect alanine aminotransferase and aspartate aminotransferase.Results Eight patients were only anti HCV positive,15 patients were only HCVRNA positive,24 patients were both anti HCV and HCVRNA positive,the total positive rate of HCV markers was 34.3%.Conclusion The prevalence of HCV infection in hemodialytic patients is serious,transaminases are not a sensitive marker for chronic hemodialytic patients.

关 键 词：血液透析 丙型肝炎病毒感染 酶学指征 ELISA RT-PCR 

分 类 号：R512.63[医药卫生—内科学]