不同剂量缬沙坦单用或与苯那普利钠联合应用对SHR血压和左室心肌肥厚的影响(英文)  

Effects of valsartan alone or in combination with benazepril on blood pressure and left ventricular hypertrophy in spontaneously hypertensive rats

作　　者：柯永胜[1] 曹蘅[1] 杨霆[1] 

机构地区：[1]皖南医学院弋矶山医院心内科,安徽芜湖241001

出　　处：《中国病理生理杂志》2001年第11期1072-1076,共5页Chinese Journal of Pathophysiology

基　　金：HealthSpecialFoundationofAnhui

摘　　要：目的 :评价不同剂量AT1受体拮抗剂valsartan单用和与benazepril联合应用对SHR的降压疗效、逆转心肌肥厚作用和对RAAS、内洋地黄素水平的影响。方法 :30只 14周龄雄性SHR随机分成空白对照组、benazepril组、小剂量valsartan组、大剂量valsartan组和小剂量valsartan与benazepril联用组 ,另设WKY正常对照组 ,分别给予生理盐水、benazepril1mg·kg-1、valsartan 8mg·kg-1、valsartan 2 4mg·kg-1、valsartan 8mg·kg-1+benazepril1mg·kg-1,每日 1次灌胃给药 ,持续 8周。结果 :药物干预各组SHR动脉收缩压 (SBP)水平明显下降 ,尤以大剂量valsartan组和联合用药组SBP下降最显著 ;药物干预各组血浆和心肌组织肾素活性均明显升高 ;benazepril组和小剂量valsartan与benazepril组血浆和心肌组织AngⅡ水平降低 ;大、小剂量valsartan组血浆和心肌组织AngⅡ水平均明显升高 ,valsartan剂量越大 ,血浆和心肌组织AngⅡ水平升高越明显 ;随SBP水平的降低 ,心肌组织Na+ -K+ -ATP酶活性明显升高 ,而内洋地黄素水平则明显下降 ;药物干预各组LVM/BW、TDM均明显减低 ,尤以联合用药组改变最为显著。结论 :不同剂量AT1拮抗剂valsartan和benazepril单用或联用均有明显的降低SHR的SBP作用 ,能明显抑制左室肥厚进展 ;AIM: To evaluate the effects of different doses of valsartan alone or with concomitant benazepril on blood pressure, left ventricular hypertrophy, RAAS function and endoxin level in spontaneously hypertensive rats (SHR). METHODS: Thirty SHR (fourteen-week-old, male) were divided into five groups (six rats in each group ): SHR control group: fed with normal saline; benazepril group: fed with 1 mg·kg -1 ·d -1 benazepril); low dose valsartan group: fed with 8 mg·kg -1 ·d -1 valsartan ; high dose valsartan group: fed with 24 mg·kg -1 ·d -1 valsartan ; combination drug therapy group: fed with valsartan (8 mg·kg -1 ·d -1 ) and benazepril (1 mg·kg -1 ·d -1 ), all for 8 weeks. WKY control group (n=6):fed with normal saline for 8 weeks.RESULTS: SBP, LVM/BW,TDM of SHR were remarkably lower than those of control after drug intervene, and effect on SBP was most remarkable in high dose valsartan group and in the combination drug therapy group; effect on LVM/BW,TDM were most remarkable in combination drug therapy group. Renin activities in plasma and myocardium were remarkably increased in drug intervene groups. The levels of Ang Ⅱ in plasma and myocardium were remarkably increased in two different dose of valsartan treating group, and the larger dose of valsartan were, the higher levels of Ang Ⅱ in plasma and myocardium were; decreased in benazepril treating group and combination drug therapy group. Na +-K +-ATPase activities in myocardium were remarkably increased and the level of endoxin in myocardium were remarkably decreased as SBP decreased after drug intervene. CONCLUSION: Different dose of valsartan alone or combined with benazepril can decrease SBP of SHR, have the effect of inhibiting progression of ventricular hypertrophy. The effect of combination drug therapy group was most remarkable among five groups and can avoid the side effect of high AngⅡ in plasma and myocardium during long-term use of valsartan alone.

关 键 词：高血压 大鼠 近交SHR 药物联合治疗 左室心肌肥厚 缬沙坦 苯那普利钠 

分 类 号：R544.1[医药卫生—心血管疾病] R542.2[医药卫生—内科学]