环磷酰胺及其制剂的二阶导数差示脉冲极谱法定量研究  

Studies on the quantitative determination of cyclophosphamide and its preparation by SDDPP

作　　者：梁云爱 李见春[2] 门孝英[2] 

机构地区：[1]山东省日照市药品检验所,山东日照276800 [2]山东省日照市人民医院,山东日照276800

出　　处：《中国药学杂志》2001年第9期620-623,共4页Chinese Pharmaceutical Journal

摘　　要：目的　建立环磷酰胺及其制剂的二阶导数差示脉冲极谱定量分析方法。方法　二阶导数差示脉冲极谱法。结果　环磷酰胺在乙醇 水 (1∶9)的溶液中 ,于 - 0 .10 1V(vsAg/AgCl)处出现一良好的二阶导数差示脉冲极谱峰 ,其峰幅值与环磷酰胺在 0 .1～ 1.4mmol·L-1范围内呈非常显著的线性关系 (P <0 .0 1) ,检测限为 9.0nmol·L-1。结论　本法简便、快速、灵敏 。OBJECTIVE: To develop an assay for the quantitative determination of the cyclophosphamide and its preparations. METHODS: The Secondary derivative differential pulse polarography was developed. RESULTS: There was a very good secondary derivative differential pulse polarogram Peak at -1.101 V (vs Ag/AgCl) in ethanol-water (1:9) solution. The linear relationship between the concentrations of sulfadimidine sodium and the peak height was good over the range of 0.1∼1.4 mmol&middotL-1 (P-1. CONCLUSION: The method is simple, accurate, rapid and sensitive.

关 键 词：环磷酰胺 二阶导数差示脉冲极谱法 定量分析 抗癌药 

分 类 号：R979.1[医药卫生—药品] R927.2[医药卫生—药学]