阿夫唑嗪的示波极谱法测定及其电化学行为  

Oscillopolarographic determination of alfuzosin and its electrochemical behavior

作　　者：曹尔新[1] 曾泳淮[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《中国药学杂志》2001年第11期763-768,共6页Chinese Pharmaceutical Journal

摘　　要：目的　研究阿夫唑嗪 (alfuzosin ,简称AFZ)的电化学行为和电极反应机制 ,拟定测定AFZ的单扫示波极谱法。方法　采用单扫示波极谱法、循环伏安法进行研究。结果　在 0 .0 1mol·L-1KH2 PO4 K2 HPO4 (pH7.0 5 )底液中 ,AFZ在汞电极上有一灵敏的导数还原峰 ,峰电位Ep=- 1.6 0V(vs.SCE) ,峰高与AFZ的浓度在 1.0× 10 -7～ 9.0× 10 -6范围内呈线性关系 (r =0 .9979) ,检出限为 3.0× 10 -8mol·L-1。该法应用于片剂中AFZ含量的测定 ,得到满意结果。结论　实验表明 ,该体系属两电子还原的不可逆吸附过程。OBJECTIVE: To study the electrochemical behavior and reduction mechanism of afluzosin (AFZ) in phosphate buffer solution. A new method for the determination of AFZ was established by single-sweep oscillopolarography. METHODS: Single-sweep oscillopolarography, cyclic voltammetry were used. RESULTS: In a supporting electrolyte of 0.01 mol&middotL-1 KH2PO4-K2HPO4 (pH7. 05), a sensitive derivative reduction peak of AFZ was found by single-sweep oscillopolarography. The peak potential was - 1.60 V (vs. SCE). The relationship between peak height and the concentration of AFZ was linear from 1.0 × 10-7 to 9.0 × 10-6 mol&middotL-1. The detection limit was 3.0 × 10-8 mol&middotL-1. The method was applied to the determination of AFZ in the sample of tablet with satisfactory results. CONCLUSION: This indicated an irreversible process with adsorption.

关 键 词：阿夫唑嗪 外用性降压药 示波极谱法 电化学行为 

分 类 号：R972.4[医药卫生—药品]