焦炉作业环境对工人血抗脂过氧化活性影响的研究  

STUDY ON EFFECTS OF ANTI-LIPID PEROXIDATION IN WORKERS EXPOSED TO COKE WORKING ENVIRONMENT

作　　者：曹多志[1] 吴金贵[1] 

机构地区：[1]马鞍山钢铁股份有限公司劳动卫生研究所

出　　处：《安徽预防医学杂志》1996年第3期3-5,共3页Anhui Journal of Preventive Medicine

摘　　要：采用１：１配对方法，测试了焦炉环境作业工人与对照组８５对不同人群的血超氧化歧化酶（ＳＯＤ）和谷光甘肽过氧化物酶（ＧＳＨ－ＰＸ）的活性变化。焦炉作业环境中焦炉逸散物（苯溶出物）平均浓度炼焦炉顶为３．３９ｍｇ／ｍ３，３．４苯并（ａ）芘平均浓度５４７．５～１０７．５ｕｇ／１００ｍ３。观察组与对照组ＳＯＤ和ＧＳＨ－ＰＸ的活性分别为１２４．４７±１６．６７（ＮＵ／ｍｌ）、１３１．５０±２３．３７（ＮＵ／ｍｌ）和１１７．１７±１７．２１（活力单位），７０．９９±１４．００（活力单位）。观察组的ＧＳＨ－ＰＸ活力在各组中均高于对照组，且Ｐ值均小于０．０１。揭示在焦炉环境下作业工人血抗脂过氧化活性增强，既可能是机体的防御性反应。The study measured activity of GSH-px and SOD from 85 couples coke oven workers and controls (exposed:control=1:1). The coke oven emissions of working environment was 3.39mg/m3,3.4-B(A)P was 547.5-107.5ug/m3. The activity of SOD、GSH-px was 124.47±16.67Nu/mL and 117.17±17.21 U in exposed workers; 131. 50±23. 37Nu/mL and 70. 99±14.00 U in control group. the results showed the activity of GSH-px was statistically increased in contrasy with control group (p<0.01). Therefore, it suggests ability of anti-lipid peroxidation was enhanced in coke oven workers, The activity of GSH0-px may be a sensitive indicator.

关 键 词：抗脂过氧化物 焦炉作业环境 炼焦作业工人 劳动卫生 职业损害 

分 类 号：R135[医药卫生—劳动卫生]