阿魏酸钠对家兔心室肌单相动作电位的影响  

Effect of sodium ferulute on monophasic action potential of Ventricular muscle in rabbit

作　　者：李屏[1] 曾秋棠[2] 周彤[3] 蔡运昌[1] 汪贵元[1] 

机构地区：[1]贵州省人民医院心内科,贵阳550002 [2]同济医科大学附属协和医院心血管病研究所,武汉430023 [3]包头钢铁职工医院,包头014000

出　　处：《中国药理学通报》2001年第5期558-561,共4页Chinese Pharmacological Bulletin

摘　　要：目的　探讨阿魏酸钠对心肌细胞单相动作电位的影响。方法　健康家兔 2 0只 ,随机平均分为两组 :对照组 (苄基四氢巴马汀组 )和实验组。按传统心内膜MAP记录方法经右颈外静脉插入四极接触电极导管至家兔右心室内膜记录MAP信号并同时记录Ⅱ导联心电图。对照组经耳缘静脉给予苄基四氢巴马汀 ( 5mg·kg-1) ,实验组给予阿魏酸钠( 0 6g·kg-1) ,给药前、后观察MAPA、MAPD5 0、MAPD90及ERP。结果　对照组用药前MAPA及MAPD2 0分别为( 2 7 0 1± 0 67)mV及 ( 79 0 5± 7 0 4 )ms,用药后分别为( 2 6 87± 0 73 )mV及 ( 77 5± 7 170 )mV(P >0 0 5 ) ;用药2 0 0 1 0 2 15收稿 ,2 0 0 1 0 4 13修回1 贵州省人民医院心内科 ,贵阳　 5 5 0 0 0 22 包头钢铁职工医院 ,包头　 0 14 0 0 0作者简介 :李　屏 ,女 ,36岁 ,医学硕士 ,副主任医师。Tel:[phone],E mail:lipingb @hotmail.com ;曾秋棠 ,男 ,36岁 ,医学博士 ,副教授 ,硕士生导师前MAPD5 0、MAPD90、ERP分别为 ( 97 5± 6 770 )ms、( 12 3 5± 5 80 )ms、( 111± 13 5 0 )ms,用药后分别为 ( 12 4 5± 8 96)ms、( 15 3± 7 5 3 )ms、( 14 2± 13 3 7)ms (P <0 0 1) ;实验组用药前MAPA及MAPD2 0分别为 ( 2 6 5 8±1 0 3 )mV及 ( 75± 5 77)ms。AIM To study sodium ferulute on monophasic action potential of ventricular muscle. METHODS Well being rabbits( n =20) were divided into 2 groups randomly,benzyltetrahydroplmatine(BTHP)group is a control group,the other is a study group. Franz's Quadrupole contact electrod catheter is advanced into the rigter ventricular by vein.MAP is recorded by traditional methods. At the same time Ⅱ lead ECG was recorded. Control group and study group were administered BTHP(5 mg·kg -1 ) and sodium ferulute(0 6 g·kg -1 ) respectively,before and after administration the duration of MAP at 20%(MAPD20),50%(MAPD50) and 90% (MAPD90) repolarization,amplitude of MAP (MAPA) and effective refractory period(ERP)were measured. RESULT In control group MAPD50,MAPD90 and ERP were significantly prolonged (124 5±8 96) ms vs (97 5±6 77) ms,(153±7 53) ms vs (123 5±5 8) ms,(142±13 37) vs (111±13 50) ms,respectively, P< 0 01. In study group MAPD50,MAPD90 and ERP were significantly prolonged to (111 9±6 19) ms vs (97±5 37) ms,(141±9 44) ms vs (121±6 58) ms,(126 5±13 95) ms vs (110±10 80) ms,respectively, P< 0 01.Two groups had no ettect on MAPA and MAPD20( P> 0 05). CONCLUSION Sodium ferulute may be potassium channel blocker.

关 键 词：阿魏酸钠 单相动作电位 钾离子通道 实验研究 

分 类 号：R972[医药卫生—药品] R285.5[医药卫生—药学]