乌头碱与钾离子通道激动剂合用对离体大鼠心脏的正性肌力作用研究  

The inotropic effects of combination of acionitine with potassium channel activator on isolated cardiac dysfunctional rat hearts

作　　者：张世忠[1] 吴博威[1] 

机构地区：[1]山西医科大学汾阳学院生理学教研室,汾阳032200

出　　处：《中国药理学通报》2001年第5期570-572,共3页Chinese Pharmacological Bulletin

摘　　要：目的　研究钾离子通道激动剂吡那地尔与乌头碱合用时乌头碱对心功能不全大鼠离体心脏的正性肌力作用。方法　本实验利用Langendorff离体心脏灌流装置 ,以左室收缩压 (LVSP)、左室压上升最大速率 ( +dp/dtmax)、左室压下降最大速率 ( -dp/dtmax)、左室舒张末压 (LVEDP)为指标 ,在①单纯使用乌头碱②乌头碱与吡那地尔 (KATP通道激动剂 )合用两种情况下 ,观察了乌头碱对腹主动脉狭窄法造成的心功能减退大鼠离体心脏的正性肌力作用。结果　实验结果表明①乌头碱对心功能不全大鼠离体心脏具有一定正性肌力作用 ,②乌头碱在激动钾通道的情况下 ,与单纯使用乌头碱相比 ,强心的有效浓度范围增大 ,强心效果明显增强 (P <0 0 5 )。结论　乌头碱对心功能减退的心脏具有强心作用 ,激动心肌钾通道可显著增强乌头碱的强心作用和有效浓度范围。AIM To investigate the positive inotropic effect of aconitine on isolated hearts from cardiac dysfunctional rats when combined with pinacidil. METHODS In our experiment Langendorff perfusion equipment was used to investigate the following cardiac indexes:LVSP(left ventricular systolic pressure), LVDP(left ventricular diastolic pressure), +d p /d t max (the maximum going up rate of left ventricular pressure) and -d p /d t max (the maximum going down rate of left ventricular pressure) from rat hearts under two conditions:① aconitine only,② aconitine plus pinacidil(an agonist of K ATP channel) to observe the positive inotropic effect of aconitine on cardiac dysfunctional rat hearts. RESULS ①Aconitine had certain positive inotropic effect on isolated hearts from cardiac dysfunctional rats; ②Combing aconitine with potassium channel activator markedly winded the doses range between the effective and toxic concentration and enhanced the cardiotonic effect of aconitine. CONCLUSION Aconitine had positive inotropic effect on dysfunctional isolated rat hearts; the combination of aconitine with potassium channel activator markedly widened the cardiotonic doses range of aconitine and enhanced its cardiotonic effect.

关 键 词：乌头碱 吡那地尔 变力性 钾离子通道激动剂 

分 类 号：R972.1[医药卫生—药品]