利洛司酮对大鼠异位子宫内膜的抑制作用(英文)  

Inhibitory effect of lilopristone on experimental endometriosis in rats

作　　者：贡沁燕[1] 李鹏[1] 施达仁[2] 姚明辉[1] 陈林爱[1] 

机构地区：[1]复旦大学基础医学院药理教研室,上海200032 [2]复旦大学附属肿瘤医院病理科,上海200032

出　　处：《中国新药与临床杂志》2001年第4期245-249,共5页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :观察利洛司酮对大鼠异位子宫内膜的抑制作用。方法 :用外科自体移植术建立大鼠子宫内膜异位症模型。灌胃给药 ,qd× 2 1d ,测量给药前、后异位内膜体积 ,计算药物对异位内膜的抑制率。结果 :用药后对照组大鼠异位子宫内膜比用药前略增大 ;给予利洛司酮 2 0 ,80mg·kg- 1和米非司酮 50mg·kg- 1后 ,异位内膜的体积比用药前明显缩小 ,抑制率依次为 (80± 2 7) % ,(88± 2 2 ) %和 (82± 31) %。结论AIM: To observe the inhibitory effect of lilopristone (Lil) on the growth of endometrial explants in rat model of endometriosis. METHODS: The model of endometriosis in rats was made by surgically autotransplanting endometrium to the peritoneum. After 3 wk, rats were laparotomized and the volumes of endometrial explants were measured. One week after second laparotomy, Lil 20, 80 mg·kg -1 , mifepristone (Mif) 50 mg·kg -1 and solvent 4 mL·kg -1 were given intragastrically (ig) qd for 21 d. At the end of treatment the volumes of endometrial explants were measured again. The inhibitory rates of the drugs on the ectopic endometrium were calculated. RESULTS: In Lil 20, 80 mg·kg -1 and Mif 50 mg·kg -1 treated rats, the growth of endometrial explant was inhibited significantly ( P < 0.01 ), with inhibitory rates of (80±27) %,(88±22) % and (82±31) %, respectively. CONCLUSION: As Mif, Lil could inhibit the growth of ectopic endometrium in rat model of endometriosis.

关 键 词：子宫内膜异位症 利洛司酮 米非司酮 治疗 实验研究 

分 类 号：R984[医药卫生—药品] R711.71[医药卫生—药学]