早期肠道营养改善烧伤大鼠胃组织血液灌流的实验研究  

Experimental study of gastric tissue blood perfusion improved by early enteral nutrition in burned rat

作　　者：彭曦[1] 冯晋斌[1] 颜洪[1] 尤忠义[1] 王裴[1] 汪仕良[1] 

机构地区：[1]第三军医大学附属西南医院烧伤研究所,重庆400038

出　　处：《重庆医学》2001年第6期517-519,共3页Chongqing medicine

摘　　要：目的　探讨早期肠道喂养改善烧伤大鼠胃组织血液灌流的机制。方法　采用 3 0 %TBSAⅢ度烧伤大鼠模型 ,随机分为正常对照 (C)、单纯烧伤 (B)和烧伤加肠道营养 (EF)组。分别检测伤前及伤后 3、6、1 2、2 4、48h胃组织中内皮素 (ET)、一氧化氮(NO)、血管活性肠肽 (VIP)含量及胃粘膜血流量 (GMBF)。结果　烧伤后胃组织中ET、NO、VIP及ET/NO、ET/VIP比值均呈上升趋势 ,而GMBF则显著低于伤前。EF组中ET含量及ET/NO、ET/VIP比值明显低于B组 ,而NO、VIP及IMBF则高于B组 ,ET/NO、ET/VIP同GMBF呈显著负相关 (r1 =- 0 93 ,P <0 0 1 ;r2 =- 0 89,P <0 0 1 )。结论　早期肠道喂养改善烧伤后胃组织缺血状况的机制可能与食物对胃肠道神经的刺激 ,导致NO、VIP释放增加 ,并适度降低ET含量有关。Objective To explore the mechanism of gastric tissue blood perfusion improved by early enteral feeding after burn injury.Methods The Wistar rats inflicted with 30% total body surface area full thickness flame burn and randomly divided into three groups:burned control(B),burned and early feeding(EF) and normal control(C).The content of endothelin(ET), nitric oxide(NO), vasoactive intestinal peptide(VIP) and gastric mucosal blood flow(GMBF)were determined at postburn 0,3,6,12,24,48h.Results The content of ET,NO,VIP in small intestine as well as the ratio of ET/NO, ET/VIP were increased significantly and the IMBF was decreased markedly postburn.In EF group ET, ET/NO and ET/VIP were significantly lower(P<0 05～0 01),and NO,VIP as well as IMBF were higher than that in B group( P <0 05～0 01).There were negative correlation between ET/NO,ET/VIP and GMBF( r =-0 93, P <0 01;r=-0 89, P <0 01)。Conclusion Our results suggested that the mechanism of gastric tissue blood perfusion improved by early enteral feeding may be correlation with increased NO, VIP and decreased ET induced by foods stimulating gut nerve.

关 键 词：早期肠道营养 胃粘膜血流量 烧伤 血液灌流 实验研究 

分 类 号：R644[医药卫生—外科学]