深低温停循环灌注降温期血气管理对婴儿脑保护的研究  

Study on the protective effect of blood gas management on brain during cooling in deep hypothermia circulatory arrest in infants

作　　者：王顺民[1] 苏肇伉[1] 徐志伟[1] 朱德明[1] 陈煜[2] 丁文祥[1] 

机构地区：[1]上海第二医科大学新华医院上海儿童医学中心小儿心胸外科,200092 [2]上海第二医科大学新华医院上海儿童医学中心小儿麻醉科,200092

出　　处：《中华小儿外科杂志》2001年第4期219-221,共3页Chinese Journal of Pediatric Surgery

基　　金：卫生部科研基金资助项目 (96 2 2 88)

摘　　要：目的　探索一种适合于小婴儿深低温停循环灌注时的脑保护血气管理策略。方法　 2 0例VSD(年龄 2～ 13个月 )婴儿按照不同血气管理和降温速度随机平均分 4组对照 ,脑功能的监测包括 :脑氧代谢参数、生化指标、脑温均匀度的比较及脑电图等。结果　快速降温期采用alpha稳态血气管理脑损害较重 ,在不同降温速度中应用 pH稳态血气管理脑损害均较轻。 结论　小婴儿深低温体外循环快速降温期应用Objective The study explored a strategy for cerebral protection of blood gas management suitable for infants during cooling perfusion in deep hypothermia circulatory arrest. Methods According to different blood gas management methods and cooling speeds, 20 cases of VSD and severe pulmonary hypertension cases ( aged 2～13 months) were randomly divided into four groups, each containing 5 cases. Parameters for preoperative cerebral function assessment included: cerebral oxygen metabolism, biochemistry factors, brain temperature gradients, EEG. Results Brain damage was relatively severe in the rapid cooling group in which alpha stat blood gas management was used. Brain damage was relatively slight in two groups that were subjected pH stat blood gas management.Conclusions pH stat blood gas management is safe and effective in protecting the brain of young infants during rapid cooling perfusion in deep hypothermia cardiopulmonary bypass.

关 键 词：血液循环 深低温停循环灌注 脑保护 血气管理 体外循环 

分 类 号：R726.1[医药卫生—儿科]