1-己胺甲酰基-5-氟尿嘧啶的新合成路线  

The New Synthetic Route of HCFU

作　　者：古凤才[1] 史云梅[1] 王彦广[1] 王金明[1] 聂建明[1] 

机构地区：[1]天津大学理学院,天津300072

出　　处：《化学工业与工程》2001年第5期269-271,307,共4页Chemical Industry and Engineering

摘　　要：本文提出了抗癌药物 1-己胺甲酰基 -5 -氟尿嘧啶不使用剧毒光气的新合成路线 :利用库尔提斯 (Curtius)重排反应从庚酸乙酯制备异氰酸己酯 ,然后再与 5 -氟尿嘧啶缩合得到产物。该合成路线操作条件温和、易于控制 ,且与环境友好。In this paper the new synthetic route of HCFU was based on the Curtius rearrangement reaction,in which HCFU was prepared by two steps. Firstly,the n -hexyl isocyanate was prepared from ethyl heptanoate and hydrzine hydrate by Curtius condensation reaction. And then the title compound was synthesized from 5-FU by using pyridine as solvent,in which the mixture of 0.1mol 5-Fu and 0.1mol n -hexyl isocyanate in pyridine was heated 3h at 95℃ to give HCFU.

关 键 词：HCFU 5-FU 异腈酸己酯 Curtius重排反应 1-己胺甲酰基-5-氟尿嘧啶 合成路线 抗癌药 

分 类 号：R979.1[医药卫生—药品] TQ254.1[医药卫生—药学]