粉檀麝香的合成研究  

Study on Synthesis of Phantolide

作　　者：晁建平[1] 杨春育[1] 焦玉海[1] 申宇太[2] 张加来 

机构地区：[1]北京石油化工学院化工系,北京102600 [2]北京燕化集团公司化工三厂研究所,北京102550

出　　处：《香料香精化妆品》2001年第3期5-6,4,共3页Flavour Fragrance Cosmetics

摘　　要：用均匀设计对粉檀麝香中间体 1,1,2 ,3,3,5 -六甲基茚满 (HMI)合成实验条件进行优化 ,使HMI的收率提高 7% ,达到了 5 7%。进而对HMI用乙酰氯进行酰化合成出合格的粉檀麝香产品 ,其总收率可达 48.1%The reaction condition of 1,1,2,3,3,5-hexamethylindan(HMI), an intermediate of synthetic Phantolide, is optimized by employing Uniform Design, and it makes the yield of HMI up to 57%(increasing 7% compared with the other reports). On the basis of the result, the qualified Phantolide also be obtained by acetylating HMI with chloride acetylate. The total yield of Phantolide can get to 48.1%.

关 键 词：粉檀麝香 合成香料 中间体 六甲基茚满 HMI 

分 类 号：TQ654[化学工程—精细化工]