电刺激引起背根节PPTA mRNA表达的变化  

THE CHANGES OF PREPROTACHYKININ A mRNA EXPRESSION INDUCED BY ELECTRIC STIMULATION IN THE NEURONS OF DORSAL ROOT GANGLION IN RATS

作　　者：李秀华[1] 赵晏[1] 史文春[1] 李信民[2] 王会生[1] 

机构地区：[1]西安交通大学医学院神经生物学研究室 [2]西安交通大学医学院第一附属医院,西安710061

出　　处：《神经解剖学杂志》2001年第3期253-256,共4页Chinese Journal of Neuroanatomy

基　　金：国家自然科学基金 ( No.39470 841);国家"八五"攀登计划经络的研究 ( No.JL 930 2 1)资助项目

摘　　要：给予大鼠背部左侧胸 9脊神经皮支电刺激后 ,用原位杂交方法观察了本节段背根节 PPTA m RNA表达的变化。证明电刺激后 2 4h,左侧胸 9节段背根节 PPTA m RNA的表达较对侧和对照组有显著增高 ( P<0 .0 1)。表明较强的电刺激可增加背根节细胞 PPTA m RNA的表达 ,提示By in situ hybridization histochemistry, the changes of preprotachykinin A(PPTA) mRNA expression were examined in the neurons of thoracal dorsal root ganglion(DRG) after a strong electric stimulation to the dorsal branch of the left ninth thoracal spinal nerve of rat. There was a significant increase in the number of neurons expressing PPTA mRNA in the ipsilateral DRG compared with the DRG of the contralateral side and control animals 24 h after the electric stimulation. The present results showed that strong electric stimulation can activate biosynthesis of PPTA mRNA in the DRG, which indicate that PPTA may play important roles in the transmission and regulation of noxious information.

关 键 词：PPTAmRNA 电刺激 原位杂交组织化学 背根节 大鼠 表达 调控 

分 类 号：R338[医药卫生—人体生理学]