含力克肺疾方案治疗老年复治菌阳肺结核的临床研究  

Clinical research of pasinizid on retreated sputum positive pulmonary tuberculosis in senilities

作　　者：余德美 王军甫 胡晓战 

机构地区：[1]西安市结核病胸部肿瘤医院,710061

出　　处：《中华结核和呼吸杂志》2001年第10期608-610,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：目的　观察和评价含力克肺疾方案治疗老年复治菌阳肺结核的疗效及安全性。方法　将 115例老年复治菌阳肺结核患者随机分入治疗组 (A组 )和对照组 (B1组、B2组 )。化疗方案 :A组以力克肺疾为主组成 3DZL2 E/ 5DL2 E ;B1组 3HPZL2 / 5HL2 E(简称HP方案 ) ;B2组 3HZL2 ES/ 5HL2 E(简称SH方案 )。采用全程监督化疗管理 ,按各自方案实施化疗。结果　疗程结束时 ,A、B1、B2组痰菌阴转率分别 92 %、72 %、71% ,A组显著高于B1组和B2组 (P <0 0 5 ) ;病灶显效率分别为 75 %、5 0 %、5 0 % ,空洞闭合率分别为 85 %、46 %、5 0 % ,A组显著高于B1组和B2组 (P <0 0 5 ) ;不良反应发生率分别为17%、5 8%、18% ,A组和B2组显著低于B1组 (P <0 0 1) ;2年细菌学复发率分别为 5 %、19%、18% ,A组显著低于B1组和B2组 (P <0 0 1)。结论　含力克肺疾方案治疗老年复治菌阳肺结核的近远期疗效均优于HP方案和SH方案 ,且不良反应发生率低 ,使用安全 。Objective To observe and evaluate the effect and safety of pasinizid on treatment of the senile pulmonary tuberculosis with bacteriological positive Methods 115 cases of the senile pulmonary tuberculosis with bacteriological positive were divided into therapy group(group A) and control group(group B1 and B2) randomly Chemotherapy regimen: group A were treated by 3DZL 2E/5DL 2E mainly composed of pasinizid; group B1 were treated by 3HPZL 2/5HL 2E(abbreviated HP regimen); group B2 were treated by 3DZL 2E/5DL 2E(abbreviated SH regimen) Results When the chemotherapy was over, the sputum negative conversion rates were 92%, 72%,71% in group A,group B1 and group B2 respectively The conversion rate in group A was significantly higher than that in group B1 and group B2 ( P <0 05); focal absorption rates were 75%,50%,50% respectively, while the vanishing rates of cavity were 85%,46%,50% respectively The rate in group A was significantly higher than that in group B1 and B2( P <0 05); Rates of side effects were 17%,58%,18% respectively The rates in group A and group B2 were apparently lower than that in group B1( P <0 01) Bacteriological relapse rate of 2 years were 5%,19%,18%, respectively The rate in group A was lower than that in group B1 and B2 ( P <0 01). Conclusions The effect of pasinizid on senile retreated sputum positive pulmonary tuberculosis was better than HP and SH regimen. Due to its lower rates of side effects,it is recommended for clinical usage

关 键 词：肺结核 复治菌阳肺结核 药物疗法 力克肺疾 治疗 临床研究 

分 类 号：R521[医药卫生—内科学] R978.3[医药卫生—临床医学]