组织工程中药物控制释放技术的应用研究  

RESEARCH AND APPLICATION OF DRUG CONTROLLED RELEASE TECHNIQUE IN TISSUE ENGINEERING

作　　者：王身国[1] 蔡晴[1] 吕泽[1] 贝建中[1] 

机构地区：[1]中国科学院化学研究所分子科学中心,北京100080

出　　处：《中国修复重建外科杂志》2001年第5期280-285,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家重点基础研究发展规划项目 ( 973;G19990 5 430 6 )~~

摘　　要：目的　研究应用药物控制释放技术 ,在组织工程中实现对生长因子的活性保护和控制释放。方法　应用药物控制释放技术 ,采用生物降解高分子对药物进行包埋或微包囊。结果　用脂肪族聚内酯为各类药物 ,包括生物活性物质的药物载体 ,通过调节脂肪族聚内酯的分子结构和控制释放方法 ,在采用聚丙交酯为神经导管和对生长因子实行包埋后 ,成功地实现了对大鼠坐骨神经 5、10、15和 2 0 mm缺损的修复。结论　可利用脂肪族聚内酯作为药物载体 ,保护各类生长因子的生物活性 。Objective To investigate protection of biological activity and controlled release of growth factor by means of drug controlled release technique in tissue engineering. Methods Using drug controlled release technique that to embed or microcapsulate the biological drug with biodegradable polymer. Results The aliphatic polylactone could be used as drug carrier for each drug including the biological matter. And the release behavior of the drug could be controlled by adjusting the molecular structure of the carrier and the controlled release method. The successful example, that to realize regeneration of rat's sciatic nerve with 5,10, 15 and 20 mm of gap by using polylactide as nerve guide and the embedding growth factor, had been obtained. Conclusion It is possible to realize protection of biological activity and sustained release of growth factor by using aliphatic polylactone as drug carrier.

关 键 词：组织工程 生长因子 生物降解高分子 脂肪族聚内酯 药物控制释放 

分 类 号：R318.0[医药卫生—生物医学工程]