生长板损伤修复的研究进展  

ADVANCE ON REPAIR OF GROWTH PLATE INJURY

作　　者：王建[1] 杨志明[1] 

机构地区：[1]华西医科大学附属第一医院骨科,成都610041

出　　处：《中国修复重建外科杂志》2001年第5期291-294,共4页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家重点基础研究发展规划项目 ( 973) :组织工程的基本科学问题 ( G19990 5 430 8) ;国家自然科学基金重点项目( 39830 10 0 )~~

摘　　要：目的　综述生长板损伤修复研究过程及其近期进展。方法　广泛查阅近期有关生长板损伤修复研究文献 ,着重阐述对生长板损伤修复的认识发展 ,比较几种主要修复方法。结果　生长板损伤修复是小儿矫形外科实验研究和临床治疗面临的一大难题。游离生长板和软骨移植 ,因缺乏血供而应用困难 ,血管化生长板移植解决了循环问题 ,但两种方法都涉及供体来源受限和免疫反应。非软骨类组织和材料只能阻止小面积生长板缺损内骨桥形成 ,无再生修复能力。组织工程软骨移植可能是生长板损伤修复的最佳选择。结论　考虑到移植物来源、修复效果及不良反应等因素 ,组织工程软骨修复生长板损伤值得进一步研究。Objective To sum up the studying course and latter development of repair of injury of growth plate. Methods Recent original articles about repair of injury of growth plate were extensively reviewed, focused on the progresses in understanding repair of injury of growth plate and comparison of several major reparative methods. Results Repair of injury of growth plate is a great difficulty in experimental study and clinical treatment of pediatric orthopedics. Graft of free growth plate and cartilage were unfavorably used because of lack of blood supplement. Although graft of vascularized growth plate solved circulation problem, both two kinds of grafts were involved in limitation of donor and immunologic reaction. Non cartilaginous tissue and material could only prevent formation of bony bridge in small defect of growth plate and lacked ability of regenerative repair. Transfer of tissue engineered cartilage might be the best choice for repair of injury of growth plate. Conclusion Considering source of transplanted material, reparative effect and adverse reaction, repair of injury of growth plate with tissue engineered cartilage deserves further investigation.

关 键 词：组织工程 软骨 修复 生长板损伤 软骨移植 

分 类 号：R68[医药卫生—骨科学]