白虎追风丸对大鼠佐剂性关节炎滑膜细胞分泌IL-1β的影响  

Effect of Baihuzhuifeng Pills on Interlukin-1β Secreted by Synoviocyte in Adjuvant Arthritis Rats

作　　者：施旭光[1] 张声鹏[1] 徐志东[1] 

机构地区：[1]广州中医药大学,广东广州510405

出　　处：《中成药》2001年第8期595-597,共3页Chinese Traditional Patent Medicine

基　　金：广东省中医药管理局资助课题 (NO .970 3 3 )

摘　　要：目的 :研究白虎追风丸对佐剂性关节炎 (AA)大鼠滑膜细胞分泌白细胞介素 1 β(IL 1β)的影响。 方法 :采用消化分离的方法获得滑膜细胞 ,采用放射免疫分析法检测原代大鼠滑膜细胞培养上清液中IL 1β的水平。 结果 :白虎追风丸可以明显下降AA大鼠滑膜细胞分泌IL 1β的水平。 结论 :提示白虑追风丸是通过下调ILObjective: To study the effect of Baihuzhuifeng Pills (BHZFP) on interleukin 1β(IL 1β) secreted by synoviocytes in adjuvant arthritis (AA) rats. Methods: Synovium of knee joints from AA rats were digested by collagenase and tripsin to prepare DSSC(digested synovial single cells). The content of the supernatant fluid was assayed by the radioimmunoassay. Results: BHZFP down regulated IL 1β productions of DSSC.Conclusion: It is suggested that BHZFP be probably inhibit the over proliferation of synoviocyte in AA rats by diminishing IL 1β secretion.

关 键 词：佐剂性关节炎 滑膜 细胞培养 白细胞介素1Β 白虎追风丸 中医药治疗 大鼠 

分 类 号：R274.943[医药卫生—中西医结合] R285.5[医药卫生—中医骨伤科学]