母乳中甲硝唑、替硝唑药动学及产妇合理哺乳时间  

Metronidazole and tinidazole pharmacokinetics in human breast milk and recommen dations for nursing neonate

作　　者：张虹[1] 夏文斌[2] 李伟[3] 陈立仁[1] 

机构地区：[1]中科院兰州化学物理研究所色谱中心,甘肃兰州730000 [2]兰州医学院第一附属医院,甘肃兰州730000 [3]兰州医学院药学系

出　　处：《中国医院药学杂志》2001年第9期517-519,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的：确定产后静滴甲硝唑及替硝唑乳妇合理的哺乳时间, 避免乳汁中药物对婴儿的不良反应。方法：采用高效液相色谱法测定乳汁药物浓度，并计算其药动学参数。结果：哺乳妇女单剂量静滴甲硝唑(20 mg·kg-1, n=8)﹑、替硝唑(13 mg·kg-1 , n=7)乳汁中药动学参 数:达峰时(Tmax)、 峰浓度(Cmax)、消除半衰期(T1/2　k e)分别是(1.7±1.0) h，(20.1±5.0 ) μg·ml-1，(6.4±3.3) h和(1.3±0.6) h，(17.2±3.1 ) μg·ml-1, (11.0±3.5) h。结论：静滴甲硝唑(20 mg·kg-1)的乳妇宜于给药后3～4 h哺乳; 静滴替硝唑(13 mg·kg -1)的乳妇宜于给药后4～6 h哺乳。：OBJECTIVE To establish the time of administration(iv infusion) of metronidazole in lactate women avoid the adverse drug reactuion of the drug to the neonate with minimal effects on the infant.METHODS Breast milk concentrations of metronidazole and tinidazole were assayed by high performance liquid chromatography(HPLC). A high performance and rapid column PE pecosphere C18 (3μm, 3.0 mm×33 mm) was used. RESULTS The p harmacokinetic parameters( ±s ) T max, C max, T 1/2ke of metronidazole (20 mg·kg-1, n =8) and tinidazole (13 mg·kg-1, n =7) in lactati on women after infusion of a single dose were (1.7±1.0) h, (20.1 ± 5.0) μg·ml-1, (6.4±3.3) h and (1.3±0.6) h, (17 .2 ±3.1) h, (11.0±3.5) μg·ml-1 respectively. The neonate dos e ingested via breast milk of metronidazole and tinidazole were 3.02 mg·kg -1·d-1 and 2.58 mg·kg-1·d-1. Percentage of materal dose of metronidazole and tini dazole were 15.1% and 19.9%. CONCLUSIONS The postpartum women were given iv do se of 20 mg·kg-1·d-1 metronidazole and of 13 mg·kg-1·d -1 tinidazole as treatment and prophylaxis against anaerobic infection. The neonate breast feeding should be ceased in 3～4 h following iv administration of metronidazole(20 mg·kg-1 ). Follo wing iv administration of tinidazole(13 mg·kg-1), the neonate breast fe eding should be ceased in 4～6 h.

关 键 词：甲硝唑 替硝唑 母乳 药动学 哺乳时间 

分 类 号：R978.61[医药卫生—药品] R174.4[医药卫生—药学]