阿莫西林胃滞留片的制备及释药特性  

Preparation and releasing properties of amoxicillin gastric r esidential tablets

作　　者：刘卫卫[1] 蒋雪涛[2] 

机构地区：[1]第二军医大学南京军医学院,江苏南京210099 [2]第二军医大学药学院,上海200433

出　　处：《中国医院药学杂志》2001年第9期526-528,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的：以卡波姆、羟丙甲基纤维素等辅料制备阿莫西林胃滞留片。方法：采用正交设计，以释放度和漂浮性为考察指标进行处方筛选。结果：以处方5为最佳处方制得的片剂具有较好的漂浮与缓释效果，稳定性研究表明，该胃滞留片 的稳定性良好。 结论：本研究制备的阿莫西林胃滞留片具有缓释、起漂时间快、稳定性好的特点。：OBJECTIVE To make amoxicillin gastric residential tablets by using carbopol and hydroxypro pylmethylcellose(HPMC). METHODS By orthogonal design, each formulation was evaluated using releasing rate and floating ability as index an d its stability properties were studied. RESULTS Formulation 5 had good floating and slow releasing rate. The stability test resu lts showed that the tablets we re stable under the test conditions. CONCLUSIONS The tablets prepared had good slow releasing rate, short afloating time and good stability.

关 键 词：阿莫西林 胃滞留片 卡波姆 羟丙甲基纤维素 Β-内酰胺类 

分 类 号：R978.11[医药卫生—药品]