藁本的抗血栓形成、利胆和抗溃疡作用  

Anti-thrombotic,Choleretic and Anti-ulcerous Actions of Rhizoma Ligustici

作　　者：张明发 沈雅琴 朱自平[2] 王红武[2] 

机构地区：[1]上海美优制药厂,上海市201423 [2]陕西省中医药研究院中药所药理室,西安市710003

出　　处：《中国药房》2001年第6期329-330,共2页China Pharmacy

基　　金：国家自然科学基金资助项目!(39370838)

摘　　要：目的 :研究藁本的抗血栓形成、利胆和抗溃疡作用。方法 :采用常规的胆汁分泌和溃疡模型以及电刺激麻醉动物颈动脉的体内血栓形成模型。结果 :给大鼠id(十二指肠给药 )或ig(灌胃给药 )藁本醇提物3g/kg 和10g/kg,促进大鼠胆汁分泌 ,延长电刺激颈动脉血栓形成时间 ,但不延长凝血酶原时间、凝血时间和白陶土部分凝血活酶时间 ;给小鼠ig5g/kg 和15g/kg,抑制水浸应激性溃疡、盐酸性溃疡和吲哚美辛 -乙醇性溃疡形成。结论 :藁本具有抗血栓形成、利胆和抗溃疡作用。OBJECTIVE:To study the anti-thrombotic,choleretic and anti-ulcerous actions of Rhizoma Ligustici METHO_DS:Experiments were carried out on conventional models of choleresis and ulceration,and on a thrombotic model of using direct current continuously to stimulate the unilateral carotid artery of anesthetic rat RESULTS:Alcoholic extract of Rhizoma Ligustici 3g herb/kg and 10g herb/kg id or ig,increased choleresis and prolonged the time for arterial thrombosis induced by electric stimulation in rats,but did not prolonged coagulative time,PT and KPTT The extract 5g herb/kg and 15g herb/kg ig,inhibited the formation of gastric ulcers induced by water immersion,stress,HCl and indomethacin-alcohol in mice CONCLU_SION:Rhizoma Ligustici has anti-thrombotic choleretic and anti-ulcerous actions

关 键 词：藁本 抗血栓形成药 利胆药 抗溃疡药 中药 

分 类 号：R282.710.5[医药卫生—中药学]