奥美拉唑胶囊人体药代动力学及相对生物利用度研究  

Study on the Pharmacokinetics and Relative Bioavalability of Omeprazole Capsules in Humans

作　　者：左六一[1] 刘贵娟[1] 邱峰[2] 何海霞[2] 周远大[2] 

机构地区：[1]重庆医科大学附属第一医院药剂科,重庆市400016 [2]重庆医科大学附属第一医院临床药理研究室,重庆市400016

出　　处：《中国药房》2001年第6期356-357,共2页China Pharmacy

摘　　要：目的 :测定奥美拉唑胶囊的药代动力学及相对生物利用度。方法 :18名志愿者单剂量随机交叉口服40mg 奥美拉唑胶囊和洛赛克胶囊 (对照品 )后 ,经高效液相色谱法测定血药浓度。结果 :口服奥美拉唑胶囊或洛赛克胶囊后 ,血药浓度达峰时间分别为 (2 10±0 64)h和 (1 88±0 70)h ,峰浓度分别为 (895 64±553 07)ng/ml和 (974 67±554 93)ng/ml,曲线下面积分别为 (1971 88±1220 98)ng/(h·ml)和 (2057 60±1306 32)ng/(h·ml)。结论 :奥美拉唑胶囊与洛赛克胶囊相比较 ,具有生物等效性。OBJECTIVE:To study the pharmacokinetics and relative bioavalability of omeprazole capsules in humans.METHO_DS:18 male healthy volunteers orally took domestic omeprazole capsules and losec capsulles(used as control)40mg respectively.Blood concentrations of drugs were determined by HPLC.RESULTS:Times to reach the peak levels of omeprazole and losec were (2 10±0 64)h and (1 88±0 70)h,the peak plasma concentrations were (895 64±553 07)ng/ml and (974 67±554 93)ng/ml and the areas under the drug concentration curves were (1 971 88±1 220 98 )ng/(h·ml) and (2 057 60±1 306 32)ng/(h·ml) respectively.CONCLUSION:The two capsules have the same bioequivalence.

关 键 词：奥美拉唑 生物利用度 高效液相色谱法 药代动力学 

分 类 号：R975[医药卫生—药品]