福康片对大鼠吗啡药代动力学的影响  

EFFECTS OF FUKANG TABLETS ON PHARMACOKINETICS OF MORPHINE IN RATS

作　　者：王玉瑾[1] 张加玲[2] 员克明[1] 刘燕娥[3] 田树华[4] 王英元[1] 

机构地区：[1]山西医科大学法医学系,太原030001 [2]山西医科大学公共卫生学院,太原030001 [3]山西职工医学院,太原030012 [4]山西医科大学医学实验中心,太原030001

出　　处：《中国药物依赖性杂志》2001年第3期179-181,共3页Chinese Journal of Drug Dependence

基　　金：山西省自然科学基金资助基金编号971052

摘　　要：目的··:研究福康片戒毒药物对大鼠吗啡药代动力学的影响。方法··:用放射免疫法 (RIA)测定了大鼠单独皮下注射 (sc)盐酸吗啡 (A组 )和合并灌胃 (ig)福康片 (B组 )后吗啡的血药浓度 ,计算两组吗啡药代动力学参数。结果··:两组吗啡药代动力学模型均符合二室模型一级吸收。B组吗啡血药浓度明显低于A组。合用福康片后 ,大鼠吗啡的t1/2ka由0.078h增加到0.164h ;Cmax由3971.143μg·L -1减少到2248.474μg·L -1 ;AUC由每小时11337.584μg·L-1 减少到8005.219μg·L-1;t1/2β 由4.091h减少到3.615h ;CL由每小时0.529L·kg-1 增加到0.750L·kg-1。Objective: To study the effects of Fukang tablets on the pharmacokinetics of morphine in rats. Method: Using RIA , the concentration of total morphine in serum of rats after pretreatment with morphine (A), and morphine with Fukang tablets (B) was determined. The pharmacokinetic parameters of morphine in A and B groups was calculated. Result: The pharmacokinetics of morphine in Group A and B showed a two-compartment model with first order absorption in the bodies of the rats. In Group B the T1/2ka and CL of morphine were increased, while the Cmax, AUC and T1/2β of morphine were decreased. Conclusion: Fukang tablets can reduce the absorbent rate of morphine and its concentration in serum, while Fukang tablets can also increase the clearance rate of morphine in rats slightly.

关 键 词：吗啡 福康片 药代动力学 放射免疫法 

分 类 号：R969.1[医药卫生—药理学]