比值光谱一阶导数法测定复方磺胺甲噁唑片中磺胺甲噁唑含量  

Determination of Sulfamethoxazole in Compound Sulfamethoxazole Tablet by First Derivative Ratio Spectrometry

作　　者：孙增先[1] 李瑞真[1] 李永溟[1] 王奎兴[1] 张骞峰[1] 周金玉[1] 

机构地区：[1]江苏省连云港市第一人民医院,连云港222002

出　　处：《光谱学与光谱分析》2001年第5期713-715,共3页Spectroscopy and Spectral Analysis

摘　　要：本文应用比值光谱一阶导数法测定复方磺胺甲唑片剂中磺胺甲唑含量 ,依据磺胺甲唑比值导数光谱用峰零法在 2 5 1nm处测定其含量 ,比值光谱一阶导数值与浓度 ( 1～ 15 μg·mL-1)线性关系良好 ,能有效消除甲氧苄啶的干扰 ,样品测定结果与药典方法比较没有显著差异 (P >0 0 5 )。The first derivative ratio spectrometry is used for the determination of sulfamethoxazole in compound sulfamethoxazole tablet.According to the first derivative ratio spectrum of sulfamethoxazole,peak-zero method is applied for the determination at 251 nm.There is a good linear correlation between the first derivative ratio spectrum value and concentration (1-15 μg·mL -1 ) for the method that can eliminate the disturbance of trimethoprim,and no difference while comparing the method with pharmacopoeia method (P>0 05).

关 键 词：比值光谱一阶导数 磺胺甲恶唑 甲氧苄啶 复方磺胺甲恶唑片 含量测定 抗菌消炎药物 

分 类 号：R978.2[医药卫生—药品] R927.2[医药卫生—药学]