新的1-取代芳基-4-乙氧羰基-5-酰胺基-1,2,3-三唑的合成及抑菌性能  

Synthesis and Antibacterial Activities of 1-Substituted Aryl-4-Ethoxycarbonyl-5-Acylamino-1,2,3-Triazoles

作　　者：陈敏东[1] 袁建超[1] 吕士杰[1] 杜小丽[2] 袁光谱[1] 杨世琰[1] 

机构地区：[1]中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室,兰州730000 [2]中国农业科学院兰州畜牧与兽药研究所

出　　处：《应用化学》2001年第10期772-776,共5页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助项目 ( 2 99330 5 0 )

摘　　要：将 1 -取代芳基 -4-乙氧羰基 -5 -氨基 -1 ,2 ,3 -连三唑与苯甲酰氯 ,氯乙酰氯 ,丙酰氯 ,乙酰氯等反应合成了 2 1种标题连三唑化合物 (1 ) ,收率在 61 %～ 91 %之间 .讨论了酰氯性质与收率之间的关系 .所有含杂环化合物的结构皆用元素分析 ,IR,1H NMR及 MS作了表征 .筛选了它们对以下细菌的抑菌性能 :Klebsiella,Escherichia coli,Psendomonas aeruginosa,Stephlococcusaureus和Twenty one new derivatives of 1 substituted aryl 4 ethoxy carbonyl 5 amino 1,2,3 triazole(compound 1) were obtained by reactions of 1 aryl 4 ethoxycarbonyl 5 amino 1,2,3 triazoles with benzoyl chloride, chloroacetyl chloride, propionyl chloride, acetyl chloride etc., in good yields( 61%~ 91%). The relationships between yields and properties of acyl halides were discussed. The structures of all heterocyclic compounds were characterized by elemental analyses, IR, 1H NMR and MS. Their antibacterial activities against Klebsiella, Escherichia coli, Pseudomonas aeruginosa, Staphlococcus aureus and Proteus vulgaris were screened.

关 键 词：合成 抑菌性能 1-取代芳基-4-乙氧羰基-5-酰胺基-1 2 3-三唑 

分 类 号：O626.26[理学—有机化学] O621.29[理学—化学]