淋巴细胞化学发光临床意义的初探  

A Preliminary Study on the Clinical Significance of Human Lymphocyte Chemiluminescence

作　　者：张学军[1] 刘琏[1] 刘亦芬[1] 毕克菊[1] 杨森[2] 刘弋[3] 夏中楠 杨林[5] 

机构地区：[1]安徽医科大学微生物学教研室,合肥230032 [2]安徽医科大学皮肤科 [3]安徽医科大学普外科 [4]安徽医科大学心内科 [5]安徽医科大学肿瘤科

出　　处：《免疫学杂志》1991年第4期252-254,共3页Immunological Journal

基　　金：安徽省教委资助课题

摘　　要：用ConA诱导人外周血淋巴细胞化学发光(Ly-CL)方法,测定112例正常人和180例不同性质疾病患者(包括肿瘤78例、银屑病39例,带状疱疹18例、病毒性心肌炎18例、湿疹17例和荨麻疹10例)Ly-CL变化。结果表明:①正常人Ly-CL变化与性别无关,而与年龄因素有关,中老年者Ly-CL低于年青者;②与相近年龄的正常人相比,肿瘤、带状疱疹、银屑病和病毒性心肌炎患者Ly-CL降低,而荨麻疹Ly-CL增高。本文结果提示,人Ly-CL变化与淋巴细胞活性或功能之间存在一定联系,不同性质疾病患者淋巴细胞产生氧自由基能力有差异。Using the method of Con A-induced chemiluminescent responses of human peripheral blood lymphocytes, we measured the intensity of lymphocyte che-milumunescence(Ly-CL) in 112 healthy donors and 180 patients with different diseases, mincluding 78 patients with Cancer, 39 patients with psoriasis, 18 patients with viral myocarditis, 18 patients with herpes zoster, 17 patients with eczema and 10 patients with urticaria. The results showed that Ly-CL intensity wasnot related to the sexuality, but related to age. Ly-CL intensity of healthy donors with old age was lower than that of healthy donors with old age. Compared with healthy donors, Ly-CL intensity of patients with cancer, psoriasis, viral myocarditis and herpes zoster obviously decreased. However, Ly-CL intensity of patients with urticaria obviously increased. Our data indicate that human Ly-CL could be related to lymphocyte activity or function and changes of oxygen free radicals produced by lymphocytes during different diseases may be altered.

关 键 词：淋巴细胞 化学发光 氧自由基 

分 类 号：R392.12[医药卫生—免疫学]