菱壳水提物对胃癌细胞抑制作用的实验研究  

Studies on inhibition effect of the aqueous extracts from water Caltrap shell on gastric cancer cell

作　　者：牛凤兰[1] 李晨旭[1] 董威严[1] 刘国良[1] 程舸[1] 张耿月[2] 任连广 王英丽[2] 

机构地区：[1]吉林大学预防医学院中心实验室,吉林长春130021 [2]吉林省肿瘤医院

出　　处：《白求恩医科大学学报》2001年第5期495-497,共3页Journal of Norman Bethune University of Medical Science

基　　金：吉林省科委基金资助项目 (95 35 48- 2)

摘　　要：目的 :观察菱壳水提取物对胃癌细胞体内外抑制作用。方法 :采用菱壳水提取物对离体培养胃癌细胞及 MFC荷瘤小鼠进行体内外实验 ,观察该提取物对胃癌细胞生长抑制率和对 MFC荷瘤小鼠生长的影响。结果 :当菱壳水提物剂量达 14.0 6 g/ L时 ,体外实验其胃癌细胞抑制率为 37.76 % ;当菱壳水提物剂量达 10 ml/ kg时 ,体内实验其抑瘤率为 36 .1% ,并存在量效关系。结论 :菱壳水提取物具有抑制胃癌细胞的作用。Objective:To explore the inhibition effect of aqueous extract from water Caltrap shell on gastric cancer cell.Methods:Experiments were made in gastric cancer cell in vitro and MFC tumor carrying mice in vivo with the aqueous extract.The inhibitive rate and growth of the tumor and the weight change of the mice were studied.Results:When the dosage reached 14.06 mg/ml,the inhibitive rate of tumor was 37.76% in vitro and the dosage reached 10 ml/kg;the inhibitive rate of tumor was 36.1% in vito.Conclusion:The aqueous extract from water Caltrap shell has the inhibitive activity to tumor.

关 键 词：菱壳 水提物 胃癌细胞 抑制作用 实验 中药 

分 类 号：R273.52[医药卫生—中西医结合] R285.5[医药卫生—中医肿瘤科]