乙肝疫苗无、弱应答与HLA-DR2、7、9相关性的研究  

Association between the feature of non-or hypo-response to hepatitis B vaccine and HLA-DR2,7,9 genes

作　　者：钱毅[1] 梁雪梅 邹东[3] 章廉[1] 胡章勇[1] 张明霞[1] 文维群[1] 侯金林[1] 

机构地区：[1]第一军医大学附属南方医院传染科,全军肝病研究中心广东广州510515 [2]广州林业学校保健科,广东广州510000 [3]解放军第157医院检验科,广东广州510515

出　　处：《免疫学杂志》2001年第6期463-465,共3页Immunological Journal

摘　　要：目的研究广东汉族人群乙肝疫苗无、弱应答水平与 HL A- DR2、7、9等位基因的相关性。方法对 140 0名广东籍汉族学生进行重组乙肝疫苗标准接种 ,末次接种后第 8周检测血清抗 - HBs抗体水平 ,对无、弱应答者和强应答者通过PCR- SSP法检测 HL A- DR2、7、9。结果无、弱应答组携带 HL A- DR2、7、9的频率分别为 5 .0 8%、15 .2 5 %和 19.49% ;强应答组携带 HL A- DR2、7、9的频率分别为 2 .2 2 % ,17.7%和 2 0 % ;2组的 HL A- DR2和 HL A- DR7间比较 ,P<0 .0 5 ;HL A- DR9间比较 ,P>0 .0 5。结论广东汉族人群乙肝疫苗无、弱应答与 HL A- DR7相关 ,与 HL A- DR2的低携带有关 ,而与 HL A-ObjectiveTo study the association between the feature of non or hypo response to hepatitis B vaccine and HLA DR2,7,9 genes among a Guangdong population of the Han nationality Methods1 400 healthy students from a Guangdong population of the Han nationality were subjected to a standard course of immunization with recombinant hepatitis B virus vaccine at month 0,1,6 Eight weeks after the last immunization, serum level of anti HBs antibody was examined with ELISA HLA DR2?7?9 alleles were conducted in non or hypo responders compared with hyper responders with polymerase chain reaction sequence specific primer(PCR SSP) ResultsThe frequency of HLA DR7 in non or hypo responders(15 25%) is higher than that in hyper responders (2 22%) ( P <0 05); The frequency of HLA DR2 in non or hypo responders(5 08%) is lower than that in hyper responders(17 7%)( P <0 05); The frequency of HLA DR9 in non or hypo responders is 19 49%, and it is 20%( P >0 05 in hyper responders ConclusionNon or hyporesponse to hepatitis B vaccine is associated with high frequency of HLA DR7,with low frequency of HLA DR2,HLA DR9 is not associated with the response to hepatitis B vaccine.

关 键 词：HLA-DR 乙肝疫苗 免疫应答 乙型肝炎 

分 类 号：R392.2[医药卫生—免疫学]