p16,cyclinD1,cdk4基因在卵巢癌中的表达及其意义  

The expression of p16,cyclin D1, cdk4, and their significance in overi an carcinoma

作　　者：祝文峰[1] 黄志锋[1] 曹亚[2] 邓雪莲[1] 李华[1] 刘文清[1] 卓缨[2] 廖伟[2] 

机构地区：[1]广东省粤北人民医院妇产科,广东韶关512026 [2]湖南医科大学肿瘤研究所,长沙410078

出　　处：《广东医学》2001年第11期1010-1012,共3页Guangdong Medical Journal

摘　　要：目的　探讨p16,cyclinD1,cdk4在卵巢癌中的表达及其意义。方法　免疫组织化学检测p16,cyclinD1,cdk4蛋白在卵巢癌中的表达 ,原位杂交检测p16和cyclinD1在卵巢癌中的存在状况。结果　p16在卵巢癌中低表达 ,cyclinD1和cdk4过度表达 ;p16与cdk4呈负相关关系 (P <0 0 5 ) ,cyclinD1与cdk4呈正相关关系 (P <0 0 5 )。结论　卵巢癌发生机制可能涉及p16,cyclinD1,cdk4调节环路中多个基因的异常 ,p16低表达和cyclinD1高表达一起在卵巢癌发生中起协同作用。Objective To study the express ion of p16,cyclin D1, cdk4 and their significance in overian carcinoma. Methods Expression of p16, cyclinD 1 and cdk4 was studied by immunchistochemi stry and in situ hybridization. Results Overexpression of cyc lin D1 and cdk4 were revealed in these samples and p16 was undertectable. Ther e was a negative correlation between p16 and cdk4 in these samples ( P<0 .05); there was a positive relation between cyclin D1 and cdk4 (P<0.05) . Conclusion Abnormality of many genes in the regulatory pathwa y of p16 and cyclin D1/cdk4 may be involved in the molecular mechanism of overia n car cinoma. Both underexpression of p16 and overexpression of cyclin D1 are important.

关 键 词：卵巢癌 基因表达 免疫组织化学 原位杂交 P16 CYCLIND1 colk4 

分 类 号：R737.31[医药卫生—肿瘤]