1.6-2磷酸果糖对脾虚大鼠血液流变学和红细胞变形性的影响  

Effect of FDP on the Deformability of Erythrocyte and Hemorheological Characteristics in Rat Model of Spleen-asthenial

作　　者：章梅[1] 邱根全[1] 夏天[2] 

机构地区：[1]西安交通大学第一医院中医科,陕西省西安市710032 [2]第四军医大学西京医院

出　　处：《中国微循环》2001年第3期206-207,共2页Journal of Chinese Microcirculation

摘　　要：目的观察1.6 -2磷酸果糖对脾虚大鼠血液流变学和红细胞变形性的影响。方法将24只Wistar大鼠随机分为脾虚组 ,脾虚组 +FDP组和对照组 ,采用LG -l90型细胞仪测定大鼠红细胞变形性和聚集性 ,采用锥板式粘度计测全血粘度。结果FDP治疗2周后 ,红细胞变形性增强 ,聚集性降低 ,全血粘度、血浆粘度、纤维蛋白原降低 ,同时可以改善心脏功能。结论FDP能明显改善脾虚大鼠红细胞变形性和血液流变特性。Objective To explore the effect of FDP on the Deformability of erythrocyte and hemorrheological characteristics and the therapeutic effect in rat model of spleen_asthenia.Methods 24 rats were divided into model of spleen-asthenia(RMSA), rats model treated with FDP(RMSA+FDP)and the controls. Erythrocyte deformability and aggregation were determined by LG-190 cellular device.Results Treated by FDP for 2 weeks, deformability of erythrocyte increased, The aggregation of erythrocyte, The whole blood viscosity, serum viscosity and fibrinogen reduced. It can also improve the heart function. Conclusions FDP can obviously improve the Deformability of erthrocyte and hemorrheological characteristics of rat model of spleen_asthenia.

关 键 词：FDP 脾虚大鼠 红细胞变形性 血液流变性 病理 

分 类 号：R256.302[医药卫生—中医内科学]