TRAIL受体及其对细胞凋亡的调控  

TRAIL RECEPORS AND THEIR CONTROL FOUNCTION IN CELL APOPTOSIS

作　　者：季军捷[1] 卫立辛[1] 时玉舫[1] 

机构地区：[1]第二军医大学国际合作肿瘤研究所,上海200433

出　　处：《中国科学基金》2001年第5期282-284,共3页Bulletin of National Natural Science Foundation of China

摘　　要：TRAIL(TNF related apoptosis inducing ligand)是新发现的肿瘤坏死因子家族(TNF)成员,能够诱导多种肿瘤细胞凋亡,其中受体决定着TRAIL的生物学功能,在TRAIL诱导的细胞凋亡中发挥着重要作用,随着研究的不断深入,发现其受体的结构组成与功能比原先所认识的更为复杂,并且在组成结构与功能上存在不一致性,提示TRAIL受体对TRAIL功能的调节具有系统性,尚有许多待认识和研究的地方,本文仅对TRAIL受体的研究新进展进行综述。TRAIL is a new member in tumor necrosis factors family. It can induce many kind tumor cells to apoptosis. The receptors decide TRAIL' s biological function and play an important role in cell apoptosis. With deep research, the structure and function of TRAIL receptors are found to be more complicated than that of anticipated. Their functions are not correspondent to their structure completely. It indicates that the regulation of TRAIL' s function is systematic and there exist lots of things unknown. The authors reviews only the new development research in TRAIL receptors.

关 键 词：TRAIL TRAIL受体 细胞凋亡 TRAIL-R1 肿瘤坏死因子 结构 功能 抗肿瘤药物 

分 类 号：R392[医药卫生—免疫学]