天南星及炮制品镇痛作用与毒性相关性的实验观察  

Experimental Observation on Relativity of Analgesic Effect to Toxicity about Arisaema amurense Maxim and Its Preparation

作　　者：刘纯[1] 石莉萍[1] 焦淑萍[2] 

机构地区：[1]北华大学,公共基础部,吉林,吉林,132013 [2]北华大学,医学院,吉林,吉林,132001

出　　处：《北华大学学报（自然科学版）》2001年第6期495-497,共3页Journal of Beihua University（Natural Science）

摘　　要：目的实验观察天南星及炮制品镇痛与毒性的相关性,寻求镇痛成分提取的可能性.方法热板法比较镇痛效果,致死时间比较毒性.结果给药0.5 h痛阚提高百分率,生药及民制品均在85%以上,生品1.5 h后便有20%死亡,用民制品次日死亡,其它制品痛阚提高百分率在70%以下,3 d后死亡.结论某毒性成分具有镇痛作用,水溶性差,提取可能.Objective To observe the relativity of analgesic effect to toxicity about Arisaema amurense and its preparation and find out possibility of purifying analgesic components.Methods The analgesic effect was compared with hot board method and the toxicity was compared with fatal time.Results Raw drug and its preparation increased pain threshold exceeding 85% after 0.5h,20% persons died after administering raw drug 1.5h. Death occurred in the next day with the preparation. Other preparation increased pain threshold under 70% and death occurred after 3 days.Conclusion The toxic components showed analgesic effect,poor dissolution and can be purified.

关 键 词：天南星 镇痛作用 毒性 中药 生药 炮制品 实验观察 镇痛成分 

分 类 号：R285.5[医药卫生—中药学]