激素敏感型单纯性肾病单核细胞呼吸道病毒及其抗体相关性研究  

A Study on the Relationship Between Respiratory Tract Viruses Antigen in Peripheral Blood Mononuclear Cells and Their Antibody from Children with Steroid-sensitive and Simple Nephrotic Syndrome

作　　者：王峥[1] 穆莉芳[1] 陶于洪[1] 袁粒星[1] 

机构地区：[1]华西医科大学附属第二医院儿科,成都610041

出　　处：《华西医科大学学报》2001年第4期559-561,共3页Journal of West China University of Medical Sciences

基　　金：国家自然科学基金资助 (批准号 39870 747)

摘　　要：目的　探讨激素敏感型单纯性肾病综合征 (SSSNS)的发病是否与呼吸道病毒感染有关。方法　采用桥联酶标法 (APAAP)和酶联免疫吸附试验 (EL ISA )检测 2 0例患儿外周血单个核细胞 (PBMC)呼吸道病毒抗原和血清病毒抗体。结果　 SSSNS患儿活动期组和缓解期组与正常对照组比较 ,其病毒检出率明显增高 (P <0 .0 5 ) ;SSSNS患儿病毒检出率与尿蛋白定量密切相关 (P <0 .0 5 ) ,2 4小时尿蛋白定量≥ 5 0 m g/ (kg· d)者的病毒检出率高于 2 4小时尿蛋白定量 <5 0 m g/ (kg· d)者 ,尿蛋白转阴时 ,体内病毒消失。结论　激素敏感型单纯性肾病综合征的发病可能与呼吸道病毒感染有关 ;Objective To explore whether respiratory tract viruses infection was involved in the pathogenesis of sterioid senstive and simple nephrotic syndrome(SSSNS). Methods Using APAAP and ELISA, the authors assayed the expression of respiratory tract viruses antigen in peripheral blood mononuclear cells(PBMC) and the production of viruses antibody in serum from 20 cases of children with steroid sensitive and simple nephrotic syndrome. Results The positive rate of viruses in the active stage group of SSSNS children increased ( P < 0.05),compared with that in the remission group and the healthy control group. The positive rate of virus detection in SSSNS children was closely related with the quantity of urinary protein( P <0.05). The positive rate of virus detection in the group with urinary protein ≥50mg/(kg·d) was higher than that in the group with urinary protein<50mg/(kg·d). Conclusion The onset of SSSNS may be related to the infection of respiratory tract viruses.

关 键 词：肾病综合征 呼吸道病毒 儿科 病因 激素敏感型 

分 类 号：R726.91[医药卫生—儿科]