机械性创伤患者血清肿瘤特异性生长因子的变化及其临床意义  

Changes Serum Level of Tumor Specific Growth Factor and Their Clinical Significance in Mechanical Trauma Patients

作　　者：张喜平[1] 李昱 吴斗[3] 吴晋普[3] 程琪辉[4] 曾小澜[4] 刘效恭[1] 

机构地区：[1]西安交通大学第二医院普外科,西安710004 [2]甘肃省凉平地区压浪县人民医院普外科 [3]山西医科大学第一附属医院 [4]山西省肿瘤医院

出　　处：《华西医科大学学报》2001年第4期569-571,共3页Journal of West China University of Medical Sciences

摘　　要：目的　研究机械性创伤患者伤后血清肿瘤特异性生长因子 (TSGF)的变化及其与创伤评分的关系 ,探讨发生原因及临床意义。方法　将 5 0例机械性创伤患者按创伤评分标准分成三组 ,轻度 31例 ,ISS≤ 16 ;重度 13例 ,16 <ISS<2 5 ;极重度 6例 ,ISS≥ 2 5 ,全部患者于伤后 2 4小时内采血 ,其中 2 5例还于 3、5、7、9、12天各采血 1次。结果　创伤后 2 4小时内各组 TSGF明显高于正常值 (P<0 .0 5 ) ,三组患者血清 TSGF呈波动性先升后降的变化 ,高峰值均出现于 7天 ,TSGF于 5 ,7,9,12天时极重度和重度 >轻度 (P<0 .0 5 )。结论　 TSGF可能与炎症反应和创伤修复有关。Objective To investigate the post traumatic changes in the serum level of tumor specific growth factor(TSGF) and their relationship with Injury Severity Score and to inquire into the possible mechanism and clincal significance. Methods Fifty patients with mechanical trauma were eligible and included. According to the standard of Injury Severity Score (ISS), the patients were divided into there groups: mild degree group,(ISS≤16, n =31) severe degreegroup (16<ISS<25, n =13) extreme severe degree group (ISS≥25, n =6). The blood samples of all patients were obtained within 24 hours, and those of 25 dynamiclly observed patients were obtained on days 3,5,7,9 and 12. Results The serum level of TSGF was significantly higher in patients with trauma in different groups ( P <0.05). The dynamical observation showed that the index demonstrated curve changes with increase in early stage and decrease later. the climax of TSGF appeared on 7 day in all 3 groups.The TSGF serum levels in extremely severe degree and severe degree groups>mild degree group on days 5,7,9 and 12 day ( P <0 05). Conclusion TSGF has relationship with the inflammatory response and recovery of trauma.

关 键 词：机械性创伤 肿瘤特异性生长因子 血清 诊断 恶性肿瘤 

分 类 号：R641[医药卫生—外科学]