家兔急性实验性心肌缺血模型高频心电图变化的探讨  

STUDIES ON CHANGES OF HIGH FREQUENCY ELECTROCARDIOGRAM DURING THE EXPERIMENTAL MODEL OF ACUTE MYOCARDIAL ISCHEMEA IN RABBITS

作　　者：顾明晖[1] 宁新宝[2] 彭正权 奚美华 郑天中[4] 

机构地区：[1]南京铁道医学院 [2]南京大学信息物理系 [3]南京市胸科医院 [4]南京医学院

出　　处：《南京大学学报（自然科学版）》1991年第3期555-561,共7页Journal of Nanjing University（Natural Science）

基　　金：宁新宝"高频心电图基础研究"科研项目内容的一部分

摘　　要：通过家免心肌缺血模型,心肌损伤模型的HF—ECG分析发现:x、y、z导联的QRS波型基本不变,分别保留缺血损伤前的qR、qRS、RS波型;而QRS波中高频成分——切迹或扭结增多,但出现的位置无明显改变。切迹大多位于QRS波波群的顶端。扭结大多位于QRS波群上升沿中段和下降沿的中下段。心肌缺血模型为可逆性病变,注药后10′—15′高频成分的个数与强度达高峰,20′后趋向恢复.心肌损伤模型为不可逆病变,HF—ECG中的切迹与扭结的个数与强度均超过心肌缺血模型,尚可出现QRS波群顶部平坦的表现,考虑为HF—ECG高频成分的另一种表现形式。 HF—ECG中的切迹和扭结的个数和强度同心肌病变程度相一致表明可通过无创伤性的HF—ECG中高频成分的变化来估计心肌病变程度。其细胞电生理机制有待于进一步实验探讨。Through the analysis of the HF-ECG of eight models of myocardial ischemea and five models of myocardial damages on five rabbits, it was found that the type of QRS wave of Channels X, Y and Z remained unchanged, maintaining the qR, qRs and RS wave type which had existed before myocardial ischemea or myocardial damages were induced. The occurring phase of the notch and the slur of the high-frequency components had little change. The notch in most cases situated on the top of the QRS waves. The slur mainly situated in the middle region of the rising slope, and the middle and bottom regions of the descending slope of the QRS waves. the number and the level of the notch and the slur increased as the myocardial condition became severe. The myocardial ischemea model was reversible: 10 to 15 minutes after injection, the number and the level of the high-frequency components reached the peak, but 20 minutes later they recovered. The model of myocardial damages was, however, irreversible. Its number and level of the notch and the slur were greater than those in the model of the myocardial ischemea. Besides, its QRS waves showed an even top, which might be regarded as another indication of the high-frequency components of the HF-ECG. The correlation between the number and level of the notch and the slur in the HF-ECF, and the intensity of the myocardial condition indicates that the latter can be estimated by the intact HF-ECG method. However, its cellular eletrophysiological mechanism still needs further experimental studies.

关 键 词：心肌缺血模型 高频心电图 心肌损伤 

分 类 号：R540.41[医药卫生—心血管疾病]