丹参酮Ⅱ_A对小鼠肝损伤的保护作用  

Protective Effect of Tanshinone ⅡA on Acute Hepatic Injury in Mice

作　　者：刘永刚[1] 陈厚昌[1] 蒋毅萍[1] 李芳哲[2] 

机构地区：[1]第一军医大学,广州510515 [2]北华大学医学院附属医院,吉林132001

出　　处：《中药材》2001年第8期588-589,共2页Journal of Chinese Medicinal Materials

摘　　要：目的:探讨丹参酮ⅡA(tanshinone Ⅱ A,TSN)对肝脏损伤的保护作用。方法:CCl_4和D-半乳糖胺小鼠肝脏损伤模型,以测定血清谷丙氨酸转换酶(ALT)、谷草氨基酸转换酶(AST)和肝匀浆丙二醛(MDA)含量为指标观察丹参酮ⅡA对肝脏损伤的保护作用。结果:丹参酮ⅡA与阳性对照药联苯双酯相仿,均能明显降低急性肝损伤小鼠的血清ALT、AST和肝匀浆MDA含量。结论:丹参酮ⅡA具有明显的保肝作用。Objective: To study the effect of tanshinone ⅡA on two models of acute hepatic injury in mice. Methods: Two acute hepatic injury models induced by carbon tetrachloride (CCl4) and D-galactosamine (D-GalN) in mice were used. ALT, AST in serum and MDA in liver homogenate were used as indexes. Results: Tanshinone Ⅱ A (10mg·kg-1, 20mg·kg-1, 30mg·kg-1), similar to biophenyldicarboxylate, could decrease ALT, AST in serum and MDA in hepatic homogenate on acute hepatic injury induced by CCl4 and D-GalN. Conclusion: Tan-shinone Ⅱ A possessed obvious protective effect against liver injury induced by CCl4 or D-GalN.

关 键 词：丹参酮ⅡA 四氯化碳 D-半乳糖胺 肝损伤 

分 类 号：R285.5[医药卫生—中药学]