胺碘酮合用小剂量β受体阻滞剂治疗老年阵发房颤临床观察  

Cordarone combined with small dose of β-blocker used to treat senile paroxysmal atrial fibrillation

作　　者：刘春萍[1] 毕磊[1] 米志琴[1] 周书明[1] 程友琴[1] 徐幼月[1] 刘青枝 

机构地区：[1]北京军区总医院干部病房一科,北京100700 [2]山西省灵丘县人民医院

出　　处：《山西医科大学学报》2001年第5期426-427,共2页Journal of Shanxi Medical University

摘　　要：目的　比较胺碘酮与小剂量 β受体阻滞剂合用对老年阵发房颤的疗效。 方法　回顾分析 3 0名老年阵发房颤患者 ,根据房颤复律后维持用药的不同 ,分为 3组 :单用胺碘酮组 (n =11) ;单用 β阻滞剂组 (n =9) ;胺碘酮与小剂量 β阻滞剂合用组(n =10 )。比较 3组患者用药后 12个月中房颤控制情况及心室率、心脏传导情况。结果　单用胺碘酮组显效率 5 4 5 % ,有效率 4 5 5 % ,无效率 0 % ;单用 β受体阻滞剂组显效率 2 2 2 % ,有效率 4 4 5 % ,无效率 3 3 3 % ;胺碘酮与小剂量 β受体阻滞剂合用治疗房颤 ,显效率 90 % ,有效率 10 % ,其疗效明显优于单用胺碘酮 (P <0 0 5 )或单用 β阻滞剂 (P <0 0 1)组 ,且未见明显副作用 :3组间心室率未见显著差别。结论　胺碘酮与小剂 β受体阻滞剂合用可有效地控制老年阵发性心房纤颤的发作。Objective To observe the therapeutic effects of combination of cordarone and small dose of β blocker on senile paroxysmal atrial fibrillation. Method Thirty patients with senile paroxysmal atrial fibrillation were divided into 3 groups according to drugs for maintenance of sinus rhythm after cardioversion of atrial fibrillation: group 1 ( n =11): cordarone;group 2 ( n= 9):β-blocker,group3( n=10 ):cordarone combined with small dose of β blocker.The recurrence of atrial fibrillation,heart rate and conduction of cadiac muscle was compared in 3 groups for 12 monthes. Results The effective rate of group 3 was 90% which was significantly higher than that of another 2 groups,and no significant side effects were observed. Conclusion Cordarone combined with small dose of β blocker can effectively and safely control the recurrence of senile paroxysmal atrial fibrillation.

关 键 词：阵发性房颤 药物疗法 胺碘酮 Β受体阻滞剂 治疗 临床观察 老年人 

分 类 号：R541.75[医药卫生—心血管疾病] R972.2[医药卫生—内科学]