阿夫唑嗪的吸附伏安特性  

Adsorptive Voltammetric Behavior of Alfuzosin

作　　者：曹尔新[1] 曾泳淮[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《中国医药工业杂志》2001年第8期362-365,共4页Chinese Journal of Pharmaceuticals

摘　　要：对阿夫唑嗪 (1)的电化学行为用单扫示波极谱、循环伏安法和常规脉冲极谱法等进行研究 ,确定了吸附伏安法测定 1的最佳条件。在 0 .0 1mol/ L KH2 PO4- K2 HPO4(p H7.0 5 )底液中 ,1在汞电极上有一线性扫描还原峰 ,该峰具有明显的吸附性。 1浓度在 1.0× 10 - 7～ 5 .0× 10 - 6 mol/ L范围内与峰电流呈线性关系 ,r=0 .9992。检出限为 1.0× 10 - 9mol/ L。The electrochemical behavior of alfuzosin (AFZ) was studied using linear sweep polarography, cyclic voltammetry and normal pulse polarography. In a supporting electrolyte containing 0.01 mol/L KH 2PO 4 K 2HPO 4(pH7.05), a reduction peak of AFZ was observed by linear sweep voltammetry at Hg electrode. The peak showed adsorptive characteristics. The relationship between peak height and the concentration of AFZ was linear from 1.0×10 -7 to 5.0×10 -6 mol/L, r =0.9992. The detection limit was 1.0×10 -9 mol/L under optimized condition.

关 键 词：阿夫唑嗪 吸附伏安特性 电化学行为 测定 外周性降压药 

分 类 号：R972.4[医药卫生—药品]